U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nlpD murein hydrolase activator NlpD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947011, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nlpD
    Official Full Name
    murein hydrolase activator NlpD
    Primary source
    ECOCYC:EG12111
    Locus tag
    b2742
    See related
    ASAP:ABE-0009004
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2737
    Summary
    NlpD in Escherichia coli is similar in sequence to the LppB lipoprotein outer membrane antigen of Haemophilus somnus, a putative virulence determinant. [More information is available at EcoCyc: EG12111].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2867614..2868753, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YgbN Neighboring gene RNA polymerase sigma factor RpoS Neighboring gene protein-L-isoaspartate O-methyltransferase Neighboring gene broad specificity 5'(3')-nucleotidase and polyphosphatase Neighboring gene tRNA pseudouridine(13) synthase Neighboring gene 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Glutathione production by efficient ATP-regenerating Escherichia coli mutants. Hara KY, et al. FEMS Microbiol Lett, 2009 Aug. PMID 19552708
    2. Identification of transcriptional start sites and the role of ppGpp in the expression of rpoS, the structural gene for the sigma S subunit of RNA polymerase in Escherichia coli. Lange R, et al. J Bacteriol, 1995 Aug. PMID 7642494, Free PMC Article
    3. The nlpD gene is located in an operon with rpoS on the Escherichia coli chromosome and encodes a novel lipoprotein with a potential function in cell wall formation. Lange R, et al. Mol Microbiol, 1994 Aug. PMID 7997184
    4. A fail-safe mechanism in the septal ring assembly pathway generated by the sequential recruitment of cell separation amidases and their activators. Peters NT, et al. J Bacteriol, 2011 Sep. PMID 21764913, Free PMC Article
    5. Structure of the 5' upstream region and the regulation of the rpoS gene of Escherichia coli. Takayanagi Y, et al. Mol Gen Genet, 1994 Jun 3. PMID 8208244

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure-function analysis revealed that the outer membrane localization of NlpD is critical for regulating its amidase activation activity.
      Title: NlpD links cell wall remodeling and outer membrane invagination during cytokinesis in Escherichia coli.
    2. The authors report that AmiB and EnvC are recruited to division sites independently of one another. The same is also true for AmiC and NlpD.
      Title: A fail-safe mechanism in the septal ring assembly pathway generated by the sequential recruitment of cell separation amidases and their activators.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    murein hydrolase activator NlpD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2867614..2868753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417222.1 murein hydrolase activator NlpD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417222.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8E0FNL0
      Conserved Domains (1) summary
      PRK10871
      Location:1 → 379
      nlpD; murein hydrolase activator NlpD
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.