U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nemR DNA-binding transcriptional repressor NemR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946166, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nemR
    Official Full Name
    DNA-binding transcriptional repressor NemR
    Primary source
    ECOCYC:G6889
    Locus tag
    b1649
    See related
    ASAP:ABE-0005514
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1645; ydhM
    Summary
    NemR is inactivated by NEM and other Cys modification reagents (Umezawa, 2008). [More information is available at EcoGene: EG13947]. YdhM is a predicted transcriptional regulator belonging to the TetR family . [More information is available at EcoCyc: G6889].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1726023..1726622)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase YdhF Neighboring gene DUF1289 domain-containing protein YdhL Neighboring gene N-ethylmaleimide reductase Neighboring gene lactoylglutathione lyase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Does the Transcription Factor NemR Use a Regulatory Sulfenamide Bond to Sense Bleach? Gray MJ, et al. Antioxid Redox Signal, 2015 Sep 20. PMID 25867078, Free PMC Article
    2. The uncharacterized transcription factor YdhM is the regulator of the nemA gene, encoding N-ethylmaleimide reductase. Umezawa Y, et al. J Bacteriol, 2008 Sep. PMID 18567656, Free PMC Article
    3. NemR is a bleach-sensing transcription factor. Gray MJ, et al. J Biol Chem, 2013 May 10. PMID 23536188, Free PMC Article
    4. Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12. Lee C, et al. Mol Microbiol, 2013 Apr. PMID 23506073
    5. Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea. Pérez-Rueda E, et al. Comput Biol Chem, 2004 Dec. PMID 15556475

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. First description of a protein whose function is regulated by a cysteine-lysine sulfenamide thiol switch, constituting a novel addition to the biological repertoire of functional redox switches, NemR.
      Title: Does the Transcription Factor NemR Use a Regulatory Sulfenamide Bond to Sense Bleach?
    2. We propose that cells have a cytosolic system consisting of the nemRA-gloA operon for the reduction of electrophiles, especially quinones and glyoxals, to maintain an appropriate intracellular redox balance.
      Title: Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12.
    3. NemR controls bleach-mediated expression of two enzymes required for detoxification of reactive electrophiles: glyoxalase I and N-ethylmaleimide reductase.
      Title: NemR is a bleach-sensing transcription factor.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding transcriptional repressor NemR

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1726023..1726622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416166.3 DNA-binding transcriptional repressor NemR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416166.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7TNQ4
      Conserved Domains (1) summary
      COG1309
      Location:1 → 195
      AcrR; DNA-binding transcriptional regulator, AcrR family [Transcription]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.