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    mipA MltA-interacting protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946301, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mipA
    Official Full Name
    MltA-interacting protein
    Primary source
    ECOCYC:G6968
    Locus tag
    b1782
    See related
    ASAP:ABE-0005928
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1780; yeaF
    Summary
    MipA is a scaffolding protein for the bifunctional murein polymerase MrcB and the lytic transglycosylase MltA. [More information is available at EcoGene: EG13492]. MipA, MltA-interacting protein, is scaffolding protein that forms a trimer with PBP1B, a murein polymerase, and MltA, a murein hydrolase . [More information is available at EcoCyc: G6968].
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    Genomic context

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    Sequence:
    NC_000913.3 (1865726..1866472, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative aldose 1-epimerase YeaD Neighboring gene methylglyoxal reductase YeaE Neighboring gene protein kinase YeaG Neighboring gene DUF444 domain-containing protein YeaH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Outer membrane proteomics of kanamycin-resistant Escherichia coli identified MipA as a novel antibiotic resistance-related protein. Li H, et al. FEMS Microbiol Lett, 2015 Jun. PMID 25940639
    2. Toxicant identification by a luminescent bacterial bioreporter panel: application of pattern classification algorithms. Elad T, et al. Environ Sci Technol, 2008 Nov 15. PMID 19068836
    3. A comparative genomics approach to prediction of new members of regulons. Tan K, et al. Genome Res, 2001 Apr. PMID 11282972, Free PMC Article
    4. Overproduction of penicillin-binding protein 2 and its inactive variants causes morphological changes and lysis in Escherichia coli. Legaree BA, et al. J Bacteriol, 2007 Jul. PMID 17513478, Free PMC Article
    5. Structural basis for intramembrane proteolysis by rhomboid serine proteases. Ben-Shem A, et al. Proc Natl Acad Sci U S A, 2007 Jan 9. PMID 17190827, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings suggested that MipA was a novel outer membrane protein related to antibiotic resistance
      Title: Outer membrane proteomics of kanamycin-resistant Escherichia coli identified MipA as a novel antibiotic resistance-related protein.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli.
    3. The effect of the dimerization of PBP1B on its activities was studied with a newly developed in vitro murein synthesis assay with radioactively labeled lipid II precursor as substrate.
      Title: In vitro murein peptidoglycan synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MltA-interacting protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1865726..1866472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416296.1 MltA-interacting protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416296.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6RUJ7
      Conserved Domains (1) summary
      COG3713
      Location:4 → 248
      OmpV; Outer membrane scaffolding protein for murein synthesis, MipA/OmpV family [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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