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    caiD crotonobetainyl-CoA hydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948995, updated on 17-Dec-2024

    Summary

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    Official Symbol
    caiD
    Official Full Name
    crotonobetainyl-CoA hydratase
    Primary source
    ECOCYC:EG11557
    Locus tag
    b0036
    See related
    ASAP:ABE-0000130
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0037; yaaL
    Summary
    Uses gamma-butyrobetainyl-CoA as co-factor. [More information is available at EcoGene: EG11557]. CaiD is a member of the crotonase superfamily; the enzyme purified from Escherichia coli O44:K74 catalyzes the hydration of crotonobetainyl-CoA to carnitinyl-CoA and can use crotonyl-CoA, but not crotonobetaine, as an alternative substrate . [More information is available at EcoCyc: EG11557].
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    Genomic context

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    Sequence:
    NC_000913.3 (35377..36162, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator CaiF Neighboring gene putative transferase CaiE Neighboring gene carnitine--CoA ligase Neighboring gene gamma-butyrobetainyl-CoA:carnitine CoA transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Cloning and expression of caiDE genes in E. coli BL21(DE3)]. Jiang J, et al. Wei Sheng Wu Xue Bao, 2000 Dec. PMID 12549051
    2. Isolation, identification, and synthesis of gamma-butyrobetainyl-CoA and crotonobetainyl-CoA, compounds involved in carnitine metabolism of E. coli. Elssner T, et al. Biochemistry, 2000 Sep 5. PMID 10978161
    3. Role of wet experiment design in data generation: from in vivo to in silico and back. Cánovas M, et al. In Silico Biol, 2007. PMID 17822388
    4. Regulation of the carnitine pathway in Escherichia coli: investigation of the cai-fix divergent promoter region. Buchet A, et al. J Bacteriol, 1998 May. PMID 9573142, Free PMC Article
    5. Identification and characterization of the caiF gene encoding a potential transcriptional activator of carnitine metabolism in Escherichia coli. Eichler K, et al. J Bacteriol, 1996 Mar. PMID 8631699, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-carnitine CoA-transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine racemase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables crotonyl-CoA hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carnitine catabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in carnitine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    crotonobetainyl-CoA hydratase
    NP_414578.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      35377..36162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414578.2 crotonobetainyl-CoA hydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414578.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7NNY1
      Conserved Domains (1) summary
      PRK03580
      Location:1 → 261
      PRK03580; crotonobetainyl-CoA hydratase
    Nucleotide Protein
    Heading Accession and Version

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