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    cvrA putative K(+):H(+) antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945755, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cvrA
    Official Full Name
    putative K(+):H(+) antiporter
    Primary source
    ECOCYC:G6620
    Locus tag
    b1191
    See related
    ASAP:ABE-0003999
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1179; ycgO
    Summary
    Previously, b4065 (yjcE) and b1191 (ycgO), have been classified as uncharacterized members of the CPA1 family of cation/proton antiport transporters. [More information is available at EcoCyc: G6620].
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    Genomic context

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    Sequence:
    NC_000913.3 (1240335..1242071, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-amino acid dehydrogenase Neighboring gene alanine racemase 2 Neighboring gene protein YmgM Neighboring gene murein tetrapeptide carboxypeptidase Neighboring gene lytic murein transglycosylase E

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Growth Inhibition by External Potassium of Escherichia coli Lacking PtsN (EIIANtr) Is Caused by Potassium Limitation Mediated by YcgO. Sharma R, et al. J Bacteriol, 2016 Jul 1. PMID 27137496, Free PMC Article
    2. Deletion of one of two Escherichia coli genes encoding putative Na+/H+ exchangers (ycgO) perturbs cytoplasmic alkali cation balance at low osmolarity. Verkhovskaya ML, et al. Microbiology (Reading), 2001 Nov. PMID 11700351
    3. Potassium/proton antiport system of Escherichia coli. Radchenko MV, et al. J Biol Chem, 2006 Jul 21. PMID 16687400
    4. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article
    5. Global topology analysis of the Escherichia coli inner membrane proteome. Daley DO, et al. Science, 2005 May 27. PMID 15919996

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overproduction of YcgO yields a potassium-sensitive phenotype with similarities to that displayed by the DeltaptsN mutation.
      Title: Growth Inhibition by External Potassium of Escherichia coli Lacking PtsN (EIIANtr) Is Caused by Potassium Limitation Mediated by YcgO.
    2. ChaA K(+)/H(+) antiporter activity enables E. coli to adapt to potassium(+) salinity stress and to maintain potassium homeostasis.
      Title: Potassium/proton antiport system of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell volume homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative K(+):H(+) antiporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1240335..1242071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415709.2 putative K(+):H(+) antiporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415709.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376JXI9
      Conserved Domains (1) summary
      COG3263
      Location:2 → 578
      NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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