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    chbR ChbR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946247, updated on 3-Dec-2024

    Summary

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    Official Symbol
    chbR
    Official Full Name
    ChbR
    Primary source
    ECOCYC:EG10143
    Locus tag
    b1735
    See related
    ASAP:ABE-0005790
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    celD; ECK1733
    Summary
    The Cel+ phenotype is due to mutations making expression chitobiose-independent, but a fully induced operon did not support growth on cellobiose, implying a mutation altering the substrate specificity is needed; several candidate mutations were noted in Genbank, but not proven to alter the specificity of the system (Keyhani, 1997). [More information is available at EcoGene: EG10143]. "Chitobiose regulator," ChbR, is a dual transcriptional factor that regulates an operon (chb) involved in transport and degradation of the -glucoside N,N'-diacetylchitobiose (chitobiose) . [More information is available at EcoCyc: EG10143].
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    Genomic context

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    Sequence:
    NC_000913.3 (1818605..1819447, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene chitooligosaccharide monodeacetylase ChbG Neighboring gene monoacetylchitobiose-6-phosphate hydrolase Neighboring gene N,N'-diacetylchitobiose-specific PTS enzyme IIA component Neighboring gene N,N'-diacetylchitobiose-specific PTS enzyme IIC component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanisms of activation of the cryptic cel operon of Escherichia coli K12. Parker LL, et al. Genetics, 1990 Mar. PMID 2179048, Free PMC Article
    2. Mutations that alter the regulation of the chb operon of Escherichia coli allow utilization of cellobiose. Kachroo AH, et al. Mol Microbiol, 2007 Dec. PMID 18028317
    3. Expression of the chitobiose operon of Escherichia coli is regulated by three transcription factors: NagC, ChbR and CAP. Plumbridge J, et al. Mol Microbiol, 2004 Apr. PMID 15066032
    4. Directed evolution of cellobiose utilization in Escherichia coli K12. Kricker M, et al. Mol Biol Evol, 1984 Feb. PMID 6400650
    5. Biochemical genetics of the cryptic gene system for cellobiose utilization in Escherichia coli K12. Kricker M, et al. Genetics, 1987 Mar. PMID 3552873, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ChbR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1818605..1819447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416249.1 ChbR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416249.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A4UR76, A4UR77, A4UR78, A4UR79, A4UR80, A4UR81, A4UR82, A4UR83, A4UR84, A4UR86, A4UR87
      Conserved Domains (1) summary
      PRK10296
      Location:2 → 279
      PRK10296; DNA-binding transcriptional regulator ChbR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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