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    ispE 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945774, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ispE
    Official Full Name
    4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
    Primary source
    ECOCYC:EG11294
    Locus tag
    b1208
    See related
    ASAP:ABE-0004056
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1196; ipk; ychB
    Summary
    [More information is available at EcoCyc: EG11294].
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    Genomic context

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    Sequence:
    NC_000913.3 (1262026..1262877, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aerobic C4-dicarboxylate transporter DauA Neighboring gene ribose-phosphate diphosphokinase Neighboring gene outer membrane lipoprotein LolB Neighboring gene glutamyl-tRNA reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis. Hirsch AK, et al. Org Biomol Chem, 2008 Aug 7. PMID 18633530
    2. Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis. Crane CM, et al. ChemMedChem, 2008 Jan. PMID 18033714
    3. A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure. Kalinowska-Tłuścik J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Mar 1. PMID 20208151, Free PMC Article
    4. Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. Lange BM, et al. Proc Natl Acad Sci U S A, 1999 Nov 23. PMID 10570138, Free PMC Article
    5. Cloning and characterization of genes involved in the biosynthesis of delta-aminolevulinic acid in Escherichia coli. Ikemi M, et al. Gene, 1992 Nov 2. PMID 1427085

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. triclinic crystal structure of the Escherichia coli IspE-ADP complex with two molecules in the asymmetric unit was determined at 2 A resolution.
      Title: A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in terpenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
    NP_415726.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1262026..1262877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415726.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415726.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A776QWR0
      Conserved Domains (1) summary
      PRK00343
      Location:1 → 272
      ipk; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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