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    deoC deoxyribose-phosphate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948902, updated on 3-Dec-2024

    Summary

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    Official Symbol
    deoC
    Official Full Name
    deoxyribose-phosphate aldolase
    Primary source
    ECOCYC:EG10221
    Locus tag
    b4381
    See related
    ASAP:ABE-0014371
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dra; ECK4373; thyR; tlr
    Summary
    DeoC is a survival protein required for MazF-mediated survival of a small subpopulation after inhibition of translation (Amitai, 2009). [More information is available at EcoGene: EG10221]. The purified enzyme may exist as both a monomer and a dimer. [More information is available at EcoCyc: EG10221].
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    Genomic context

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    Sequence:
    NC_000913.3 (4617323..4618102)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative patatin-like phospholipase YjjU Neighboring gene putative metal-dependent hydrolase YjjV Neighboring gene putative glycyl-radical enzyme activating enzyme YjjW Neighboring gene DUF3029 domain-containing protein YjjI Neighboring gene thymidine phosphorylase Neighboring gene phosphopentomutase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tandem CRP binding sites in the deo operon of Escherichia coli K-12. Valentin-Hansen P. EMBO J, 1982. PMID 6329724, Free PMC Article
    2. Directed evolution of an industrial biocatalyst: 2-deoxy-D-ribose 5-phosphate aldolase. Jennewein S, et al. Biotechnol J, 2006 May. PMID 16892289
    3. Crystallization and preliminary crystallographic data for class I deoxyribose-5-phosphate aldolase from Escherichia coli: an application of reverse screening. Stura EA, et al. Proteins, 1995 May. PMID 7675789
    4. Genetic mapping of a mutation in Escherichia coli showing reduced activity of thymidine phosphorylase. Dale B, et al. J Bacteriol, 1967 Sep. PMID 5340684, Free PMC Article
    5. Deoxyribonucleoside catabolism and thymine incorporation in mutants of Escherichia coli lacking deoxyriboaldolase. Munch-Petersen A. Eur J Biochem, 1970 Jul. PMID 4923156

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Direct detection of potential selenium delivery proteins by using an Escherichia coli strain unable to incorporate selenium from selenite into proteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyribose-phosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribose-phosphate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxyribose-phosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-deoxyribose 1-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in carbohydrate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within carbohydrate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deoxyribonucleotide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deoxyribonucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within deoxyribonucleotide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deoxyribose phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleobase-containing small molecule interconversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    deoxyribose-phosphate aldolase
    NP_418798.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4617323..4618102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418798.1 deoxyribose-phosphate aldolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418798.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MCS7
      Conserved Domains (1) summary
      PRK05283
      Location:2 → 259
      PRK05283; deoxyribose-phosphate aldolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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