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    htpX protease HtpX [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946076, updated on 3-Dec-2024

    Summary

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    Official Symbol
    htpX
    Official Full Name
    protease HtpX
    Primary source
    ECOCYC:EG10462
    Locus tag
    b1829
    See related
    ASAP:ABE-0006087
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1828
    Summary
    Overexpression of truncated HtpX promotes degradation of incomplete proteins in puromycin-treated cells. [More information is available at EcoGene: EG10462]. HtpX is a heat shock protein that may be involved in degrading misfolded proteins . [More information is available at EcoCyc: EG10462].
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    Genomic context

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    Sequence:
    NC_000913.3 (1911695..1912576, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor KdgR Neighboring gene putative transporter YebQ Neighboring gene tail-specific protease Neighboring gene RNA chaperone ProQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation, characterization, and sequence of an Escherichia coli heat shock gene, htpX. Kornitzer D, et al. J Bacteriol, 1991 May. PMID 1826904, Free PMC Article
    2. Sequence similarity analysis of Escherichia coli proteins: functional and evolutionary implications. Koonin EV, et al. Proc Natl Acad Sci U S A, 1995 Dec 5. PMID 8524875, Free PMC Article
    3. Cpx signaling pathway monitors biogenesis and affects assembly and expression of P pili. Hung DL, et al. EMBO J, 2001 Apr 2. PMID 11285215, Free PMC Article
    4. Quality control of cytoplasmic membrane proteins in Escherichia coli. Akiyama Y. J Biochem, 2009 Oct. PMID 19454621
    5. Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli. Sakoh M, et al. J Biol Chem, 2005 Sep 30. PMID 16076848

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to temperature stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protease HtpX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1911695..1912576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416343.1 protease HtpX [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416343.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AI00
      Conserved Domains (1) summary
      PRK05457
      Location:1 → 290
      PRK05457; protease HtpX
    Nucleotide Protein
    Heading Accession and Version

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