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    cyoA cytochrome bo3 subunit 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945080, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cyoA
    Official Full Name
    cytochrome bo3 subunit 2
    Primary source
    ECOCYC:EG10178
    Locus tag
    b0432
    See related
    ASAP:ABE-0001495
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0426
    Summary
    2 IM TMS; cleavable signal peptide can be incorrectly predicted as a third TMS. [More information is available at EcoGene: EG10178]. CyoA is subunit II of the cytochrome bo terminal oxidase complex encoded by cyoABCDE. [More information is available at EcoCyc: EG10178].
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    Genomic context

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    Sequence:
    NC_000913.3 (450663..451610, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bo3 subunit 4 Neighboring gene cytochrome bo3 subunit 3 Neighboring gene cytochrome bo3 subunit 1 Neighboring gene muropeptide:H(+) symporter Neighboring gene putative lipoprotein YajG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex. van der Oost J, et al. J Mol Biol, 1993 Feb 5. PMID 8433374
    2. Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center. Wilmanns M, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618822, Free PMC Article
    3. Glutamate-89 in subunit II of cytochrome bo3 from Escherichia coli is required for the function of the heme-copper oxidase. Ma J, et al. Biochemistry, 1999 Nov 16. PMID 10563797
    4. Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases. Mogi T, et al. Biochim Biophys Acta, 2009 Feb. PMID 19111521
    5. Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA. van Bloois E, et al. J Biol Chem, 2006 Apr 14. PMID 16481320

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. No evidence of low affinity ubiquinone binding site in cytochrome bo3 from Escherichia coli.
      Title: Searching for the low affinity ubiquinone binding site in cytochrome bo(3) from Escherichia coli.
    2. Data suggest that in RsCcO(aa3), the E286 mutations severely perturb the active site, while he local structure around E286 in EcQO(bo3) is different, providing a rationale for the different effects of E286 mutations in the two enzymes.
      Title: Differential effects of glutamate-286 mutations in the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo(3) ubiquinol oxidase from Escherichia coli.
    3. Removal of three terminal cytochrome oxidase genes (cydAB, cyoABCD, and cbdAB) and a quinol monooxygenase gene (ygiN) from the Escherichia coli K-12 MG1655 genome resulted in the activation of ArcA aerobically.
      Title: Deletion of genes encoding cytochrome oxidases and quinol monooxygenase blocks the aerobic-anaerobic shift in Escherichia coli K-12 MG1655.
    4. analysis of translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA
      Title: Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.
    5. Data show that the distinct domains of CyoA have different translocation requirements (YidC only and Sec/YidC) and confirms that the membrane biogenesis of subunit II of cytochrome oxidase in bacteria and mitochondria have conserved features.
      Title: Membrane biogenesis of subunit II of cytochrome bo oxidase: contrasting requirements for insertion of N-terminal and C-terminal domains.
    6. CyoA is a substrate of a novel pathway that involves both SecYEG and YidC
      Title: Subunit a of cytochrome o oxidase requires both YidC and SecYEG for membrane insertion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytochrome bo3 ubiquinol oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytochrome bo3 ubiquinol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to cytochrome-c oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-c oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreduction-driven active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within aerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within aerobic respiration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within electron transport coupled proton transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in electron transport coupled proton transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cytochrome o ubiquinol oxidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytochrome o ubiquinol oxidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome bo3 subunit 2
    NP_414966.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      450663..451610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414966.1 cytochrome bo3 subunit 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414966.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3LGY6
      Conserved Domains (1) summary
      PRK10525
      Location:1 → 315
      PRK10525; cytochrome o ubiquinol oxidase subunit II; Provisional
    Nucleotide Protein
    Heading Accession and Version

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