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    wcaA UDP-glucuronate:2-O-Ac-beta-D-Gal-(1->3)-alpha-L-Fuc-(1->4)-2/3-O-Ac-alpha-L-Fuc-(1->3)-beta-D-Glc-PP-Und beta-(1,3)-glucuronosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946570, updated on 3-Dec-2024

    Summary

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    Official Symbol
    wcaA
    Official Full Name
    UDP-glucuronate:2-O-Ac-beta-D-Gal-(1->3)-alpha-L-Fuc-(1->4)-2/3-O-Ac-alpha-L-Fuc-(1->3)-beta-D-Glc-PP-Und beta-(1,3)-glucuronosyltransferase
    Primary source
    ECOCYC:G7104
    Locus tag
    b2059
    See related
    ASAP:ABE-0006816
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2053
    Summary
    WcaA is believed to be a glycosyl transferase involved in colanic acid synthesis based on sequence similarity and its presence in a putative colanic acid synthesis operon . [More information is available at EcoCyc: G7104].
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    Genomic context

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    Sequence:
    NC_000913.3 (2132558..2133397, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene colanic acid polymerase Neighboring gene colanic acid biosynthesis galactosyltransferase WcaC Neighboring gene colanic acid biosynthesis acetyltransferase WcaB Neighboring gene protein-tyrosine kinase Wzc Neighboring gene protein-tyrosine phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overproduction of exopolysaccharides by an Escherichia coli K-12 rpoS mutant in response to osmotic stress. Ionescu M, et al. Appl Environ Microbiol, 2009 Jan. PMID 18997023, Free PMC Article
    2. Escherichia coli RcsA, a positive activator of colanic acid capsular polysaccharide synthesis, functions To activate its own expression. Ebel W, et al. J Bacteriol, 1999 Jan. PMID 9882673, Free PMC Article
    3. Identification of the promoter region for the colanic acid polysaccharide biosynthetic genes in Escherichia coli K-12. Stout V. J Bacteriol, 1996 Jul. PMID 8763957, Free PMC Article
    4. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
    5. Development of a biofilm production-deficient Escherichia coli strain as a host for biotechnological applications. Sung BH, et al. Appl Environ Microbiol, 2006 May. PMID 16672475, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within colanic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within colanic acid biosynthetic process IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in slime layer polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronate:2-O-Ac-beta-D-Gal-(1->3)-alpha-L-Fuc-(1->4)-2/3-O-Ac-alpha-L-Fuc-(1->3)-beta-D-Glc-PP-Und beta-(1,3)-glucuronosyltransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2132558..2133397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416563.1 UDP-glucuronate:2-O-Ac-beta-D-Gal-(1->3)-alpha-L-Fuc-(1->4)-2/3-O-Ac-alpha-L-Fuc-(1->3)-beta-D-Glc-PP-Und beta-(1,3)-glucuronosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416563.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A895NJG4
      Conserved Domains (1) summary
      TIGR04017
      Location:1 → 279
      WcaA; colanic acid biosynthesis glycosyl transferase WcaA
    Nucleotide Protein
    Heading Accession and Version

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