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    cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit [ Danio rerio (zebrafish) ]

    Gene ID: 170581, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cacna1cprovided by ZNC
    Official Full Name
    calcium channel, voltage-dependent, L type, alpha 1C subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020129-1
    See related
    Ensembl:ENSDARG00000008398 AllianceGenome:ZFIN:ZDB-GENE-020129-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    isl; C-LTCC
    Summary
    Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including calcium ion import; embryonic organ morphogenesis; and physiological cardiac muscle hypertrophy. Predicted to be located in several cellular components, including T-tubule; perikaryon; and postsynaptic density membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in central nervous system; digestive system; lateral plate mesoderm; pericardial region; and splanchnocranium. Human ortholog(s) of this gene implicated in Brugada syndrome 3; Timothy syndrome; long QT syndrome 8; and neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See cacna1c in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20308987..20480303)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (20596310..20759327)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 38 like Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4a Neighboring gene leucine-rich repeats and transmembrane domains 2a Neighboring gene decapping mRNA 1B Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene integrator complex subunit 13 Neighboring gene Ras association domain family member 8b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow. Andersen ND, et al. J Mol Cell Cardiol, 2015 Mar. PMID 25536179, Free PMC Article
    2. Improved selection of zebrafish CRISPR editing by early next-generation sequencing based genotyping. Sieliwonczyk E, et al. Sci Rep, 2023 Jan 27. PMID 36707549, Free PMC Article
    3. Calcium handling in zebrafish ventricular myocytes. Zhang PC, et al. Am J Physiol Regul Integr Comp Physiol, 2011 Jan. PMID 20926764
    4. Primary cilium regulates CaV1.2 expression through Wnt signaling. Muntean BS, et al. J Cell Physiol, 2014 Dec. PMID 24700505, Free PMC Article
    5. Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation. Pluimer BR, et al. iScience, 2023 Jul 21. PMID 37416451, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LITAF acts as an adaptor protein promoting NEDD4-mediated ubiquitination and subsequent degradation of L-type calcium channel.
      Title: LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase.
    2. CaV1.2 expression is tightly regulated through Wnt signaling and plays an essential sensory role in primary cilia necessary for cellular homeostasis
      Title: Primary cilium regulates CaV1.2 expression through Wnt signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within physiological cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IC
    Inferred by Curator
    more info
    		  
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent L-type calcium channel subunit alpha-1C
    Names
    ZfCav1.2
    island beat

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131900.1 → NP_571975.1  voltage-dependent L-type calcium channel subunit alpha-1C

      See identical proteins and their annotated locations for NP_571975.1

      Status: PROVISIONAL

      Source sequence(s)
      AF305689
      UniProtKB/TrEMBL
      A0A8M3B905, Q90ZA7
      Related
      ENSDARP00000031067.4, ENSDART00000028856.5
      Conserved Domains (4) summary
      pfam00520
      Location:1248 → 1504
      Ion_trans; Ion transport protein
      pfam08763
      Location:1577 → 1648
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1671 → 2095
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1512 → 1575
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      20308987..20480303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219495.1 → XP_068075596.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X2

      UniProtKB/TrEMBL
      A0A8M9QAX1

    2. XM_068219497.1 → XP_068075598.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X4

      UniProtKB/TrEMBL
      A0A8M9PGZ0

    3. XM_068219506.1 → XP_068075607.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X14

      UniProtKB/TrEMBL
      A0A8M9PGZ0

    4. XM_068219494.1 → XP_068075595.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1

      UniProtKB/TrEMBL
      A0A8M9PU44

    5. XM_068219501.1 → XP_068075602.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X8

      UniProtKB/TrEMBL
      A0A8M9PU44

    6. XM_068219504.1 → XP_068075605.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X12

      UniProtKB/TrEMBL
      A0A8M9PU44

    7. XM_068219496.1 → XP_068075597.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q5Q9

    8. XM_068219505.1 → XP_068075606.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X13

      UniProtKB/TrEMBL
      A0A8M9Q5Q9

    9. XM_068219500.1 → XP_068075601.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X7

      UniProtKB/TrEMBL
      A0A8M9QAX6

    10. XM_068219502.1 → XP_068075603.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X9

      UniProtKB/TrEMBL
      A0A8M9PGZ0

    11. XM_021474920.2 → XP_021330595.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X20

      UniProtKB/TrEMBL
      A0A8M9QAY0, A0A8M9QAY5
      Conserved Domains (4) summary
      pfam00520
      Location:156 → 452
      Ion_trans; Ion transport protein
      pfam08763
      Location:1583 → 1654
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1677 → 2110
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1511 → 1581
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    12. XM_068219499.1 → XP_068075600.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X6

      UniProtKB/TrEMBL
      A0A8M9Q055

    13. XM_068219498.1 → XP_068075599.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X5

      UniProtKB/TrEMBL
      A0A8M9PU44

    14. XM_021474904.2 → XP_021330579.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X11

      UniProtKB/TrEMBL
      A0A8M9PU44, A0A8M9Q050
      Conserved Domains (4) summary
      pfam00520
      Location:1253 → 1527
      Ion_trans; Ion transport protein
      pfam08763
      Location:1600 → 1671
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1694 → 2129
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1528 → 1598
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    15. XM_021474912.2 → XP_021330587.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X15

      UniProtKB/TrEMBL
      A0A8M9PGZ5, A0A8M9PU55
      Conserved Domains (4) summary
      pfam00520
      Location:1253 → 1511
      Ion_trans; Ion transport protein
      pfam08763
      Location:1584 → 1655
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1678 → 2113
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1512 → 1582
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    16. XM_021474913.2 → XP_021330588.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X16

      UniProtKB/TrEMBL
      A0A8M9PU49, A0A8M9Q061
      Conserved Domains (4) summary
      pfam00520
      Location:1253 → 1511
      Ion_trans; Ion transport protein
      pfam08763
      Location:1584 → 1655
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1678 → 2113
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1512 → 1582
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    17. XM_068219507.1 → XP_068075608.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X21

      UniProtKB/TrEMBL
      A0A8M9Q061

    18. XM_021474919.2 → XP_021330594.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X19

      UniProtKB/TrEMBL
      A0A8M9Q061, A0A8M9Q067
      Conserved Domains (4) summary
      pfam00520
      Location:1252 → 1510
      Ion_trans; Ion transport protein
      pfam08763
      Location:1583 → 1654
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1677 → 2110
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1511 → 1581
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    19. XM_021474916.2 → XP_021330591.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X17

      UniProtKB/TrEMBL
      A0A8M9PU55, A0A8M9Q5R3
      Conserved Domains (4) summary
      pfam00520
      Location:1253 → 1511
      Ion_trans; Ion transport protein
      pfam08763
      Location:1584 → 1655
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1678 → 2111
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1512 → 1582
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    20. XM_021474917.2 → XP_021330592.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X18

      UniProtKB/TrEMBL
      A0A8M9PH00, A0A8M9Q061
      Conserved Domains (4) summary
      pfam00520
      Location:1253 → 1511
      Ion_trans; Ion transport protein
      pfam08763
      Location:1584 → 1655
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1678 → 2111
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1512 → 1582
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    21. XM_068219503.1 → XP_068075604.1  voltage-dependent L-type calcium channel subunit alpha-1C isoform X10

      UniProtKB/TrEMBL
      A0A8M3B905
    Nucleotide Protein
    Heading Accession and Version

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