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    aqpZ water channel AqpZ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945497, updated on 17-Dec-2024

    Summary

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    Official Symbol
    aqpZ
    Official Full Name
    water channel AqpZ
    Primary source
    ECOCYC:EG13270
    Locus tag
    b0875
    See related
    ASAP:ABE-0002976
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    bniP; ECK0866
    Summary
    AqpZ-dependent water permeability increases as cells enter stationary phase. [More information is available at EcoGene: EG13270]. AqpZ is a water channel, or aquaporin, that allows bi-directional passive diffusion of water in Escherichia coli. [More information is available at EcoCyc: EG13270].
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    Genomic context

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    Sequence:
    NC_000913.3 (915352..916047, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein S-nitrosylase Neighboring gene L-lysine/thialysine exporter Neighboring gene DUF2813 domain-containing protein YbjD Neighboring gene DUF535 domain-containing protein YbjX Neighboring gene ABC-type tripartite efflux pump membrane fusion protein Neighboring gene ABC-type tripartite efflux pump ATP binding/membrane subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy. Tan H, et al. Biochim Biophys Acta Biomembr, 2022 Feb 1. PMID 34624277
    2. Isolation of a gene encoding nodulin-like intrinsic protein of Escherichia coli. Fushimi K, et al. Biochem Mol Biol Int, 1997 Apr. PMID 9137831
    3. The aquaporin-Z water channel gene of Escherichia coli: structure, organization and phylogeny. Calamita G, et al. Biol Cell, 1997 Aug. PMID 9468603
    4. Regulation of the Escherichia coli water channel gene aqpZ. Calamita G, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520416, Free PMC Article
    5. Visualization of AqpZ-mediated water permeability in Escherichia coli by cryoelectron microscopy. Delamarche C, et al. J Bacteriol, 1999 Jul. PMID 10400575, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy.
      Title: Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy.
    2. Positive cooperativity in the activation of E. coli aquaporin Z by cardiolipin: Potential for lipid-based aquaporin modulators.
      Title: Positive cooperativity in the activation of E. coli aquaporin Z by cardiolipin: Potential for lipid-based aquaporin modulators.
    3. Induction of an immune response against AqpZ or its homologous regions can also trigger an autoimmune reaction against human Aqp4 and inflammation of the central nervous system.
      Title: Cross-immunoreactivity between bacterial aquaporin-Z and human aquaporin-4: potential relevance to neuromyelitis optica.
    4. Data show that the open and closed states of AqpZ directly relate to the side chain conformation of residue R189.
      Title: Water permeation dynamics of AqpZ: a tale of two states.
    5. biochemical analysis of permeability and solute transport characteristics of amphiphilic triblock-polymer vesicles containing the bacterial water-channel protein Aquaporin Z
      Title: Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z.
    6. analysis of of Escherichia coli aquaporin AqpZ and GlpF single-channel water permeabilities
      Title: Single-channel water permeabilities of Escherichia coli aquaporins AqpZ and GlpF.
    7. the 2.5 A resolution structure of AqpZ suggests aquaporin selectivity results both from a steric mechanism due to pore size and from specific amino acid substitutions that regulate the preference for a hydrophobic or hydrophilic substrate
      Title: Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z.
    8. the difference in Arg-189 displacements is correlated with a strong electron density between first transmembrane helices of two open channels; the observed Arg-189 conformations are stabilized by asymmetrical subunit interactions in tAqpZ
      Title: Crystal structure of AqpZ tetramer reveals two distinct Arg-189 conformations associated with water permeation through the narrowest constriction of the water-conducting channel.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables water channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables water channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in water transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in water transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in water transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    water channel AqpZ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      915352..916047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415396.1 water channel AqpZ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415396.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7IEG3
      Conserved Domains (1) summary
      PRK05420
      Location:1 → 231
      PRK05420; aquaporin Z; Provisional
    Nucleotide Protein
    Heading Accession and Version

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