pigp phosphatidylinositol glycan anchor biosynthesis, class P [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pigpprovided by ZNC
Official Full Name: phosphatidylinositol glycan anchor biosynthesis, class Pprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4041
See related: Ensembl:ENSDARG00000038805 AllianceGenome:ZFIN:ZDB-GENE-030131-4041
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dscr5; zgc:73366; wu:fc66d08
Summary: Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Acts upstream of or within convergent extension involved in axis elongation; regulation of JNK cascade; and regulation of convergent extension involved in gastrulation. Predicted to be located in membrane. Is expressed in blastomere; central nervous system; and somite. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 55. Orthologous to human PIGP (phosphatidylinositol glycan anchor biosynthesis class P). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (110879..116036)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (110395..116036)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol N-acetylglucosaminyltransferase subunit P

Names: Down syndrome critical region gene 5; phosphatidylinositol glycan, class P

NP_956006.2

EC 2.4.1.198

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199712.2 → NP_956006.2 phosphatidylinositol N-acetylglucosaminyltransferase subunit P

Status: VALIDATED

Source sequence(s)

CU633885, FO681335

UniProtKB/TrEMBL

A0A2R8Q1D2, A0A8M1PBS0

Related

ENSDARP00000147536.1, ENSDART00000190467.1

Conserved Domains (1) summary

pfam08510
Location:13 → 126

PIG-P; PIG-P