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    pdk2b pyruvate dehydrogenase kinase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 393971, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pdk2bprovided by ZNC
    Official Full Name
    pyruvate dehydrogenase kinase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-939
    See related
    Ensembl:ENSDARG00000059054 AllianceGenome:ZFIN:ZDB-GENE-040426-939
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Pdk; pdk2; zgc:56209
    Summary
    Predicted to enable pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in regulation of acetyl-CoA biosynthetic process from pyruvate and regulation of glucose metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in cardiac ventricle. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See pdk2b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (5674912..5687743)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (5756660..5769491)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch211-264f5.2 Neighboring gene alpha(1,3)fucosyltransferase gene 2 Neighboring gene alpha(1,3)fucosyltransferase gene 1 Neighboring gene zgc:174904 Neighboring gene si:ch211-264f5.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. Sips PY, et al. PLoS One, 2018. PMID 29879736, Free PMC Article
    2. A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity. Lim ET, et al. Am J Hum Genet, 2014 Nov 6. PMID 25439097, Free PMC Article
    3. The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio). Dios S, et al. Zebrafish, 2014 Oct. PMID 25181277, Free PMC Article
    4. HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably. Kopp R, et al. Physiol Genomics, 2011 May 13. PMID 21343420
    5. Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome. Kumar MG, et al. eNeuro, 2016 Mar-Apr. PMID 27066534, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC56209

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate dehydrogenase kinase 2b
    Names
    pyruvate dehydrogenase kinase, isoenzyme 2
    pyruvate dehydrogenase kinase, isoenzyme 2b
    pyruvate dehydrogenase kinase, isozyme 2b
    NP_957290.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200996.1 → NP_957290.1  pyruvate dehydrogenase kinase 2b

      See identical proteins and their annotated locations for NP_957290.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045993
      UniProtKB/TrEMBL
      A0A8M9P1R7, Q7ZV57
      Related
      ENSDARP00000042188.6, ENSDART00000042189.7
      Conserved Domains (3) summary
      smart00387
      Location:242 → 362
      HATPase_c; Histidine kinase-like ATPases
      COG0642
      Location:196 → 370
      BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
      pfam10436
      Location:30 → 192
      BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      5674912..5687743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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