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    ghxP guanine/hypoxanthine transporter GhxP [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948565, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ghxP
    Official Full Name
    guanine/hypoxanthine transporter GhxP
    Primary source
    ECOCYC:EG11939
    Locus tag
    b4064
    See related
    ASAP:ABE-0013319
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4057; yjcD
    Summary
    YjcD belongs to a superfamily of xanthine/uracil permeases. [More information is available at EcoGene: EG11939]. Membrane topology predictions using experimentally determined C terminus locations indicate that YagU has 13 transmembrane helices and the C-terminus is located in the periplasm . [More information is available at EcoCyc: EG11939].
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    Genomic context

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    Sequence:
    NC_000913.3 (4278479..4279828)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator SoxS Neighboring gene DNA-binding transcriptional dual regulator SoxR Neighboring gene ncRNA Neighboring gene putative transporter YjcE Neighboring gene pentapeptide repeat-containing protein YjcF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A critical role for the putative NCS2 nucleobase permease YjcD in the sensitivity of Escherichia coli to cytotoxic and mutagenic purine analogs. Kozmin SG, et al. mBio, 2013 Oct 29. PMID 24169576, Free PMC Article
    2. Transport of nucleic acid bases into Escherichia coli. Burton K. J Gen Microbiol, 1983 Nov. PMID 6198438
    3. Functional identification of the hypoxanthine/guanine transporters YjcD and YgfQ and the adenine transporters PurP and YicO of Escherichia coli K-12. Papakostas K, et al. J Biol Chem, 2013 Dec 27. PMID 24214977, Free PMC Article
    4. Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes. Blattner FR, et al. Nucleic Acids Res, 1993 Nov 25. PMID 8265357, Free PMC Article
    5. Identification of co-regulated genes through Bayesian clustering of predicted regulatory binding sites. Qin ZS, et al. Nat Biotechnol, 2003 Apr. PMID 12627170

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables guanine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleobase transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine nucleobase transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within guanine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hypoxanthine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleobase transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleobase transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine/hypoxanthine transporter GhxP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4278479..4279828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418488.1 guanine/hypoxanthine transporter GhxP [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418488.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6R8V4
      Conserved Domains (1) summary
      COG2252
      Location:9 → 447
      AzgA; Xanthine/uracil/vitamin C permease, AzgA family [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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