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    nanE putative N-acetylmannosamine-6-phosphate 2-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947745, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nanE
    Official Full Name
    putative N-acetylmannosamine-6-phosphate 2-epimerase
    Primary source
    ECOCYC:G7677
    Locus tag
    b3223
    See related
    ASAP:ABE-0010575
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3212; yhcJ
    Summary
    NanE is not predicted to be a lipoprotein by LipOP or PATOSEQ, but is listed in DOLOP as a putative lipoprotein. [More information is available at EcoGene: EG12816]. NanE is predicted to encode N-acetylmannosamine-6-phosphate epimerase, an enzyme involved in the utilization of N-acetylneuraminate and N-acetylmannosamine as carbon sources . [More information is available at EcoCyc: G7677].
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    Genomic context

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    Sequence:
    NC_000913.3 (3370347..3371036, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1016 domain-containing protein YhcG Neighboring gene N-acetylneuraminate anomerase Neighboring gene N-acetylmannosamine kinase Neighboring gene N-acetylneuraminate:H(+) symporter Neighboring gene N-acetylneuraminate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of GlcNAc-6-P 2-epimerase from Escherichia coli K92. Ferrero MA, et al. Acta Biochim Pol, 2007. PMID 17565386
    2. The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli. Rodionova IA, et al. J Bacteriol, 2018 Mar 1. PMID 29229699, Free PMC Article
    3. Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase. Ohta Y, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3909108, Free PMC Article
    4. Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. Kalivoda KA, et al. J Bacteriol, 2003 Aug. PMID 12897000, Free PMC Article
    5. Diversity of microbial sialic acid metabolism. Vimr ER, et al. Microbiol Mol Biol Rev, 2004 Mar. PMID 15007099, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We provide evidence here that NanE, GlcNAc-6P epimerase, and the uridylylated PII protein allosterically activate NagB by direct protein-protein interactions.
      Title: The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables N-acylglucosamine-6-phosphate 2-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acylglucosamine-6-phosphate 2-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acylglucosamine-6-phosphate 2-epimerase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylmannosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within N-acetylmannosamine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in N-acetylmannosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative N-acetylmannosamine-6-phosphate 2-epimerase
    NP_417690.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3370347..3371036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417690.1 putative N-acetylmannosamine-6-phosphate 2-epimerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417690.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6V2N6, A0A831M649
      Conserved Domains (1) summary
      COG3010
      Location:1 → 227
      NanE; Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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