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    nuoM NADH:quinone oxidoreductase subunit M [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947731, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nuoM
    Official Full Name
    NADH:quinone oxidoreductase subunit M
    Primary source
    ECOCYC:EG11773
    Locus tag
    b2277
    See related
    ASAP:ABE-0007529
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2271; nuoA
    Summary
    NuoM and NuoL are located at the distal end of the membrane arm. the redox centers are in the peripheral arm. [More information is available at EcoGene: EG11773]. NuoM is part of the inner membrane component of NADH dehydrogenase I . [More information is available at EcoCyc: EG11773].
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    Genomic context

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    Sequence:
    NC_000913.3 (2391512..2393041, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YfbP Neighboring gene NADH:quinone oxidoreductase subunit N Neighboring gene NADH:quinone oxidoreductase subunit L Neighboring gene NADH:quinone oxidoreductase subunit K Neighboring gene NADH:quinone oxidoreductase subunit J

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Features of subunit NuoM (ND4) in Escherichia coli NDH-1: TOPOLOGY AND IMPLICATION OF CONSERVED GLU144 FOR COUPLING SITE 1. Torres-Bacete J, et al. J Biol Chem, 2009 Nov 27. PMID 19815558, Free PMC Article
    2. Single particle analysis confirms distal location of subunits NuoL and NuoM in Escherichia coli complex I. Baranova EA, et al. J Struct Biol, 2007 Aug. PMID 17360196
    3. The transmembrane helices of the L, M, and N subunits of Complex I from E. coli can be assigned on the basis of conservation and hydrophobic moment analysis. Vik SB. FEBS Lett, 2011 Apr 20. PMID 21420404
    4. Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function. Michel J, et al. PLoS One, 2011 Feb 28. PMID 21387012, Free PMC Article
    5. A requirement for anaerobically induced redox functions during aerobic growth of Escherichia coli with serine, glycine and leucine as carbon source. Lan J, et al. Res Microbiol, 2003 Apr. PMID 12706508

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. To explore the functional relevance of the pseudosymmetric inverted-repeat structures of the antiporter-like subunits NuoL/M/N, we constructed a symmetry-related structure of a possible alternate-access state.
      Title: Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I.
    2. Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function.
      Title: Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function.
    3. Data show that in L, M, and N subunits of Complex I, transmembrane helices 9 and 12 are predicted to form the discontinuous helices, which are likely to play a key role in function.
      Title: The transmembrane helices of the L, M, and N subunits of Complex I from E. coli can be assigned on the basis of conservation and hydrophobic moment analysis.
    4. Data show that none of the mutants showed alteration in the detectable levels of expressed NuoM or on the NDH-1 assembly.
      Title: Features of subunit NuoM (ND4) in Escherichia coli NDH-1: TOPOLOGY AND IMPLICATION OF CONSERVED GLU144 FOR COUPLING SITE 1.
    5. Data show that subunits NuoL and M jointly occupy a distal half of the membrane domain of respiratory complex I, separated by about 10nm from the interface with the peripheral arm.
      Title: Single particle analysis confirms distal location of subunits NuoL and NuoM in Escherichia coli complex I.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    contributes_to NADH dehydrogenase (ubiquinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to NADH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquinone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquinone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in electron transport coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in electron transport coupled proton transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADH dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of respiratory chain complex I NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH:quinone oxidoreductase subunit M
    NP_416780.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2391512..2393041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416780.1 NADH:quinone oxidoreductase subunit M [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416780.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JR71
      Conserved Domains (1) summary
      PRK05846
      Location:1 → 509
      PRK05846; NADH:ubiquinone oxidoreductase subunit M; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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