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    sdaA L-serine deaminase I [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946331, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sdaA
    Official Full Name
    L-serine deaminase I
    Primary source
    ECOCYC:EG10930
    Locus tag
    b1814
    See related
    ASAP:ABE-0006039
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1812
    Summary
    L-serine deaminase I (SdaA) is one of three enzymes carrying out the sole step in the pathway of L-serine degradation, converting serine into a basic cellular building block, pyruvate. [More information is available at EcoCyc: EG10930].
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    Genomic context

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    Sequence:
    NC_000913.3 (1896932..1898296)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aminodeoxychorismate synthase subunit 1 Neighboring gene putative NUDIX hydrolase with low 3-phosphohydroxypyruvate phosphatase activity Neighboring gene putative c-di-GMP phosphodiesterase PdeD Neighboring gene TerC family inner membrane protein YoaE Neighboring gene protein YoaL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro and in vivo activation of L-serine deaminase in Escherichia coli K-12. Newman EB, et al. J Bacteriol, 1985 Jun. PMID 3888962, Free PMC Article
    2. In vitro studies on L-serine deaminase activity of Escherichia coli K12. Newman EB, et al. Can J Biochem, 1980 Nov. PMID 7011505
    3. Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli. Wiebe MA, et al. mBio, 2022 Dec 20. PMID 36468870, Free PMC Article
    4. Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis. Cicchillo RM, et al. J Biol Chem, 2004 Jul 30. PMID 15155761
    5. Deficiency in l-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12. Zhang X, et al. Mol Microbiol, 2008 Aug. PMID 18532981

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli.
      Title: Serine Deamination Is a New Acid Tolerance Mechanism Observed in Uropathogenic Escherichia coli.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Use of gene fusions of the structural gene sdaA to purify L-serine deaminase 1 from Escherichia coli K-12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-serine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-serine ammonia-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-serine ammonia-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-serine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-serine deaminase I
    NP_416328.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1896932..1898296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416328.1 L-serine deaminase I [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416328.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AJJ6, A0A7A6VR80
      Conserved Domains (1) summary
      PRK15023
      Location:1 → 454
      PRK15023; L-serine deaminase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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