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    Plg plasminogen [ Mus musculus (house mouse) ]

    Gene ID: 18815, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plgprovided by MGI
    Official Full Name
    plasminogenprovided by MGI
    Primary source
    MGI:MGI:97620
    See related
    Ensembl:ENSMUSG00000059481 AllianceGenome:MGI:97620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pg
    Summary
    Enables kinase binding activity. Involved in trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including embryonic placenta development; muscle cell cellular homeostasis; and myoblast differentiation. Located in cell surface. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in early conceptus; embryo; liver; and secondary oocyte. Human ortholog(s) of this gene implicated in COVID-19; conjunctivitis; hereditary angioedema; plasminogen deficiency type I; and thrombophilia. Orthologous to human PLG (plasminogen). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 538.8), liver adult (RPKM 533.8) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Plg in Genome Data Viewer
    Location:
    17 A1; 17 8.5 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12597496..12638271)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12378609..12419384)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41855 Neighboring gene serologically defined colon cancer antigen 3 pseudogene Neighboring gene predicted gene, 41527 Neighboring gene solute carrier family 22 (organic cation transporter), member 3 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene RIKEN cDNA C030013G03 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables apolipoprotein binding  
    enables endopeptidase activity  
    enables endopeptidase activity  
    enables enzyme binding  
    enables kinase binding PubMed 
    enables kinase binding  
    enables protease binding  
    enables protein antigen binding  
    enables protein domain specific binding  
    enables protein-folding chaperone binding  
    enables serine-type endopeptidase activity  
    enables serine-type endopeptidase activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in biological process involved in interaction with symbiont  
    involved_in blood coagulation  
    involved_in blood coagulation  
    involved_in extracellular matrix disassembly  
    involved_in fibrinolysis  
    involved_in fibrinolysis  
    acts_upstream_of_or_within labyrinthine layer blood vessel development PubMed 
    acts_upstream_of_or_within mononuclear cell migration PubMed 
    acts_upstream_of_or_within muscle cell cellular homeostasis PubMed 
    acts_upstream_of_or_within myoblast differentiation PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis PubMed 
    involved_in negative regulation of cell-substrate adhesion  
    involved_in negative regulation of fibrinolysis  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of fibrinolysis  
    acts_upstream_of_or_within protein processing PubMed 
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in proteolysis involved in protein catabolic process  
    acts_upstream_of_or_within tissue regeneration PubMed 
    involved_in tissue remodeling  
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission PubMed 
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission PubMed 
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission PubMed 
    acts_upstream_of_or_within trophoblast giant cell differentiation PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in cell surface PubMed 
    located_in cell surface  
    located_in collagen-containing extracellular matrix PubMed 
    located_in external side of plasma membrane  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 

    General protein information

    Preferred Names
    plasminogen
    Names
    angiostatin
    plasmin heavy chain A
    plasmin light chain B
    NP_032903.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008877.3NP_032903.3  plasminogen precursor

      See identical proteins and their annotated locations for NP_032903.3

      Status: VALIDATED

      Source sequence(s)
      AK132254, BY131661, J04766
      Consensus CDS
      CCDS28390.1
      UniProtKB/Swiss-Prot
      P20918, Q8CIS2, Q91WJ5
      UniProtKB/TrEMBL
      Q3V1T9
      Related
      ENSMUSP00000014578.6, ENSMUST00000014578.7
      Conserved Domains (4) summary
      smart00020
      Location:581805
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:273354
      KR; Kringle domain
      cd00190
      Location:582807
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01099
      Location:3897
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      12597496..12638271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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