Fem1b fem 1 homolog b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fem1bprovided by MGI
Official Full Name: fem 1 homolog bprovided by MGI
Primary source: MGI:MGI:1335087
See related: Ensembl:ENSMUSG00000032244 AllianceGenome:MGI:1335087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0396
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Acts upstream of or within branching involved in prostate gland morphogenesis; epithelial cell maturation involved in prostate gland development; and protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Used to study type 2 diabetes mellitus. Orthologous to human FEM1B (fem-1 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 35.7), placenta adult (RPKM 32.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 33.87 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (62699106..62718930, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (62791824..62811648, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fem1b is a binding partner of Ankrd37, and their interaction resulted in Ankrd37 degradation through the ubiquitin-mediated proteolysis pathway.
Title: Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37.
Increased Fem1b is associated with intestinal neoplasia.
Title: Fem1b antigen in the stool of ApcMin mice as a biomarker of early Wnt signaling activation in intestinal neoplasia.
Fem1b may have a conserved role in the generation of sexual dimorphism through its interaction with Nkx3.1 in the developing prostate gland
Title: Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development.
neither FEM1B nor PHTF1 are directly implicated in apoptosis in testis tissue
Title: Putative homeodomain transcription factor 1 interacts with the feminization factor homolog fem1b in male germ cells.
Fem1b is implicated in pancreatic islet function and insulin secretion
Title: Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236159

NoName (e-PCR)
- UniSTS:236160

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables death receptor binding	IEA Inferred from Electronic Annotation more info
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell maturation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA damage checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul2-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein fem-1 homolog B

Names: F1A-alpha; FEM1-beta; fem-1-like death receptor-binding protein alpha; fem-1-like in apoptotic pathway protein alpha; feminization 1 homolog b; mt-Fem

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010193.4 → NP_034323.1 protein fem-1 homolog B

See identical proteins and their annotated locations for NP_034323.1

Status: VALIDATED

Source sequence(s)

AI854655, AK122272, AK149329, AK160393, CJ047815

Consensus CDS

CCDS23266.1

UniProtKB/Swiss-Prot

Q3TV57, Q3ULQ3, Q3V148, Q80U13, Q99NC9, Q9QZL3, Q9Z2G0

Related

ENSMUSP00000034775.9, ENSMUST00000034775.10

Conserved Domains (4) summary

cd00204
Location:87 → 207

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:87 → 118

ANK; ANK repeat [structural motif]

pfam12796
Location:11 → 117

Ank_2; Ankyrin repeats (3 copies)

cl26073
Location:101 → 366

Ank_2; Ankyrin repeats (3 copies)