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    Nudt4 nudix hydrolase 4 [ Mus musculus (house mouse) ]

    Gene ID: 71207, updated on 14-Dec-2024

    Summary

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    Official Symbol
    Nudt4provided by MGI
    Official Full Name
    nudix hydrolase 4provided by MGI
    Primary source
    MGI:MGI:1918457
    See related
    Ensembl:ENSMUSG00000020029 AllianceGenome:MGI:1918457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIPP2; DIPP-2; HDCMB47P; DIPP2beta; DIPP2alpha; 4933436C10Rik
    Summary
    Enables snoRNA binding activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to several human genes including NUDT4 (nudix hydrolase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 90.4), colon adult (RPKM 66.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nudt4 in Genome Data Viewer
    Location:
    10 C2; 10 49.42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95382869..95400008, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95547007..95564146, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46239 Neighboring gene STARR-seq mESC enhancer starr_27642 Neighboring gene ubiquitin-conjugating enzyme E2N Neighboring gene STARR-positive B cell enhancer ABC_E8362 Neighboring gene STARR-seq mESC enhancer starr_27645 Neighboring gene microRNA 3058 Neighboring gene predicted gene, 33336 Neighboring gene STARR-seq mESC enhancer starr_27652 Neighboring gene anaphase promoting complex C subunit 15, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple mRNA decapping enzymes in mammalian cells. Song MG, et al. Mol Cell, 2010 Nov 12. PMID 21070968, Free PMC Article
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol-polyphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables diphosphoinositol-polyphosphate diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diphosphoinositol polyphosphate phosphohydrolase 2
    Names
    diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2
    nucleoside diphosphate-linked moiety X motif 4
    nudix (nucleoside diphosphate linked moiety X)-type motif 4
    nudix motif 4
    NP_001345925.1
    NP_081998.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358996.1 → NP_001345925.1  diphosphoinositol polyphosphate phosphohydrolase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK017075, AK048062, BP753270, CJ208434
      Conserved Domains (1) summary
      cd04666
      Location:18 → 137
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    2. NM_027722.5 → NP_081998.3  diphosphoinositol polyphosphate phosphohydrolase 2 isoform 2

      See identical proteins and their annotated locations for NP_081998.3

      Status: VALIDATED

      Source sequence(s)
      AK017075, AK048062, CJ208434
      Consensus CDS
      CCDS24138.1
      UniProtKB/Swiss-Prot
      Q8BXB9, Q8R2U6, Q9D3T6
      UniProtKB/TrEMBL
      Q4FJR0
      Related
      ENSMUSP00000020217.6, ENSMUST00000020217.7
      Conserved Domains (1) summary
      cd04666
      Location:18 → 136
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      95382869..95400008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2U6.1 GenPept UniProtKB/Swiss-Prot:Q8R2U6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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