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    Zbtb16 zinc finger and BTB domain containing 16 [ Mus musculus (house mouse) ]

    Gene ID: 235320, updated on 27-Dec-2024

    Summary

    Official Symbol
    Zbtb16provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 16provided by MGI
    Primary source
    MGI:MGI:103222
    See related
    Ensembl:ENSMUSG00000066687 AllianceGenome:MGI:103222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    lu; PLZF; Zfp145
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein homodimerization activity; and transcription corepressor binding activity. Acts upstream of or within several processes, including embryonic pattern specification; limb morphogenesis; and male germ-line stem cell asymmetric division. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 8.1), subcutaneous fat pad adult (RPKM 7.3) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Zbtb16 in Genome Data Viewer
    Location:
    9 A5.3; 9 26.47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48563097..48747525, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (48651797..48836225, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5067 Neighboring gene nicotinamide N-methyltransferase Neighboring gene STARR-seq mESC enhancer starr_24071 Neighboring gene STARR-seq mESC enhancer starr_24072 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:48458381-48458564 Neighboring gene predicted gene, 53521 Neighboring gene predicted gene, 32280 Neighboring gene STARR-seq mESC enhancer starr_24076 Neighboring gene STARR-seq mESC enhancer starr_24078 Neighboring gene STARR-seq mESC enhancer starr_24080 Neighboring gene STARR-seq mESC enhancer starr_24081 Neighboring gene predicted gene, 32335 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3A Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    involved_in cartilage development  
    acts_upstream_of cell population proliferation PubMed 
    involved_in embryonic digit morphogenesis  
    acts_upstream_of_or_within embryonic hindlimb morphogenesis PubMed 
    involved_in embryonic hindlimb morphogenesis  
    acts_upstream_of_or_within embryonic limb morphogenesis  
    acts_upstream_of_or_within embryonic pattern specification PubMed 
    acts_upstream_of_or_within forelimb morphogenesis PubMed 
    involved_in hemopoiesis  
    acts_upstream_of_or_within hindlimb morphogenesis PubMed 
    acts_upstream_of_or_within male germ-line stem cell asymmetric division PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in ossification involved in bone maturation  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
    involved_in positive regulation of cartilage development  
    involved_in positive regulation of chondrocyte differentiation  
    involved_in positive regulation of fat cell differentiation  
    involved_in positive regulation of ossification  
    involved_in protein localization to nucleus  
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within skeletal system development PubMed 
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in PML body  
    located_in male germ cell nucleus PubMed 
    located_in nuclear body  
    located_in nuclear speck  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of protein-containing complex  
    part_of transcription repressor complex  

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 16
    Names
    Green's luxoid
    zinc finger protein 145

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033324.3NP_001028496.1  zinc finger and BTB domain-containing protein 16

      See identical proteins and their annotated locations for NP_001028496.1

      Status: VALIDATED

      Source sequence(s)
      AC113548, AK142947
      Consensus CDS
      CCDS23158.1
      UniProtKB/TrEMBL
      Q3UQ17
      Related
      ENSMUSP00000091374.4, ENSMUST00000093852.5
      Conserved Domains (3) summary
      COG5048
      Location:448622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18205
      Location:16122
      BTB_POZ_ZBTB16_PLZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16)
    2. NM_001364543.1NP_001351472.1  zinc finger and BTB domain-containing protein 16

      Status: VALIDATED

      Source sequence(s)
      AC113548, CT009741
      Consensus CDS
      CCDS23158.1
      UniProtKB/TrEMBL
      Q3UQ17
      Related
      ENSMUSP00000150887.2, ENSMUST00000216150.2
      Conserved Domains (3) summary
      COG5048
      Location:448622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18205
      Location:16122
      BTB_POZ_ZBTB16_PLZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16)
    3. NM_001410497.1NP_001397426.1  zinc finger and BTB domain-containing protein 16

      Status: VALIDATED

      Source sequence(s)
      AC113548, CT009741
      UniProtKB/TrEMBL
      Q3UQ17

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      48563097..48747525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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