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    Adora3 adenosine A3 receptor [ Mus musculus (house mouse) ]

    Gene ID: 11542, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adora3provided by MGI
    Official Full Name
    adenosine A3 receptorprovided by MGI
    Primary source
    MGI:MGI:104847
    See related
    Ensembl:ENSMUSG00000000562 AllianceGenome:MGI:104847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A3R; A3AR; AA3R; ARA3; Gpcr2
    Summary
    This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. This gene shares its 3' terminal exon with a transcript variant from overlapping GeneID:69296, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
    Expression
    Biased expression in testis adult (RPKM 3.8), mammary gland adult (RPKM 1.0) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Adora3 in Genome Data Viewer
    Location:
    3 F2.2; 3 46.45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105811737..105816244)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105904421..105908928)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RAS-related protein 1a Neighboring gene STARR-positive B cell enhancer ABC_E10203 Neighboring gene STARR-positive B cell enhancer ABC_E11208 Neighboring gene STARR-seq mESC enhancer starr_08637 Neighboring gene predicted gene 5547 Neighboring gene STARR-seq mESC enhancer starr_08638 Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_08639 Neighboring gene STARR-positive B cell enhancer ABC_E9566 Neighboring gene STARR-positive B cell enhancer ABC_E9567 Neighboring gene RIKEN cDNA I830077J02 gene Neighboring gene STARR-seq mESC enhancer starr_08641 Neighboring gene ATP synthase peripheral stalk-membrane subunit b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC118217

    Gene Ontology Provided by MGI

    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway  
    acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway PubMed 
    involved_in G protein-coupled receptor signaling pathway  
    acts_upstream_of calcium-mediated signaling PubMed 
    acts_upstream_of calcium-mediated signaling PubMed 
    acts_upstream_of_or_within histamine secretion by mast cell PubMed 
    acts_upstream_of_or_within histamine secretion by mast cell PubMed 
    acts_upstream_of mast cell degranulation PubMed 
    acts_upstream_of mast cell degranulation PubMed 
    acts_upstream_of mucus secretion PubMed 
    acts_upstream_of mucus secretion PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling PubMed 
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling PubMed 
    acts_upstream_of_or_within positive regulation of inflammatory response PubMed 
    acts_upstream_of_or_within positive regulation of inflammatory response PubMed 
    acts_upstream_of_or_within positive regulation of leukocyte migration PubMed 
    acts_upstream_of_or_within positive regulation of leukocyte migration PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation PubMed 
    acts_upstream_of_or_within positive regulation of mast cell degranulation PubMed 
    acts_upstream_of_or_within positive regulation of mucus secretion PubMed 
    acts_upstream_of_or_within positive regulation of mucus secretion PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in regulation of norepinephrine secretion  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse  
    is_active_in dendrite  
    is_active_in neuromuscular junction PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in presynaptic membrane  
    is_active_in synapse  
    is_active_in synapse PubMed 

    General protein information

    Preferred Names
    adenosine receptor A3
    Names
    G-protein coupled receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009631.4NP_033761.2  adenosine receptor A3

      See identical proteins and their annotated locations for NP_033761.2

      Status: VALIDATED

      Source sequence(s)
      AC121847, AK013534, BY585192
      Consensus CDS
      CCDS17712.1
      UniProtKB/Swiss-Prot
      Q61618, Q9R202
      UniProtKB/TrEMBL
      Q3U4C5
      Related
      ENSMUSP00000000574.2, ENSMUST00000000574.3
      Conserved Domains (2) summary
      pfam00001
      Location:30283
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:22128
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      105811737..105816244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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