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    Rcbtb2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 105670, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rcbtb2provided by MGI
    Official Full Name
    regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2provided by MGI
    Primary source
    MGI:MGI:1917200
    See related
    Ensembl:ENSMUSG00000022106 AllianceGenome:MGI:1917200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chc1l; RC/BTB2; 2610028E02Rik; 2810420M18Rik
    Summary
    Acts upstream of or within several processes, including digestive tract development; hematopoietic or lymphoid organ development; and liver development. Located in acrosomal vesicle. Used to study malignant histiocytic disease. Orthologous to human RCBTB2 (RCC1 and BTB domain containing protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 22.6), CNS E11.5 (RPKM 17.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rcbtb2 in Genome Data Viewer
    Location:
    14 D3; 14 38.66 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (73376185..73421495)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (73138745..73184055)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene cysteinyl leukotriene receptor 2 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:73516811-73517104 Neighboring gene predicted gene, 35388 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:73518865-73519018 Neighboring gene predicted gene, 52109 Neighboring gene STARR-seq mESC enhancer starr_37111 Neighboring gene RB transcriptional corepressor 1 Neighboring gene microRNA 687 Neighboring gene STARR-seq mESC enhancer starr_37112 Neighboring gene VISTA enhancer mm1341 Neighboring gene lysophosphatidic acid receptor 6

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    RCC1 and BTB domain-containing protein 2
    Names
    regulator of chromosome condensation and BTB domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170694.1NP_001164165.1  RCC1 and BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_001164165.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA119207, AK031248, AK160881, CX209814
      Consensus CDS
      CCDS27266.1
      UniProtKB/Swiss-Prot
      G1EE51, Q3TUA3, Q8BMG2, Q99LJ7
      UniProtKB/TrEMBL
      E9Q3B1
      Related
      ENSMUSP00000131588.2, ENSMUST00000164822.8
      Conserved Domains (3) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    2. NM_134083.4NP_598844.3  RCC1 and BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_598844.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA119207, AK031242, AK160881, CX209814
      Consensus CDS
      CCDS27266.1
      UniProtKB/Swiss-Prot
      G1EE51, Q3TUA3, Q8BMG2, Q99LJ7
      UniProtKB/TrEMBL
      E9Q3B1
      Related
      ENSMUSP00000022702.7, ENSMUST00000022702.13
      Conserved Domains (3) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

    RNA

    1. NR_033185.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CT571265

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      73376185..73421495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518384.2XP_006518447.1  RCC1 and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006518447.1

      UniProtKB/Swiss-Prot
      G1EE51, Q3TUA3, Q8BMG2, Q99LJ7
      UniProtKB/TrEMBL
      E9Q3B1
      Conserved Domains (3) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    2. XM_006518386.3XP_006518449.1  RCC1 and BTB domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006518449.1

      UniProtKB/TrEMBL
      E9Q3B1
      Conserved Domains (3) summary
      COG5184
      Location:83311
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:350466
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:463527
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    3. XM_006518388.3XP_006518451.1  RCC1 and BTB domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      COG5184
      Location:13175
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:214330
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:327391
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    4. XM_011244891.4XP_011243193.1  RCC1 and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243193.1

      UniProtKB/Swiss-Prot
      G1EE51, Q3TUA3, Q8BMG2, Q99LJ7
      UniProtKB/TrEMBL
      E9Q3B1
      Conserved Domains (3) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    5. XM_036158375.1XP_036014268.1  RCC1 and BTB domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      COG5184
      Location:13175
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:214330
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:327391
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    6. XM_036158377.1XP_036014270.1  RCC1 and BTB domain-containing protein 2 isoform X5

      Conserved Domains (2) summary
      COG5184
      Location:13175
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl38908
      Location:214303
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    7. XM_030247592.2XP_030103452.1  RCC1 and BTB domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      E9Q3B1
      Conserved Domains (2) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl38908
      Location:374463
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    8. XM_011244892.4XP_011243194.1  RCC1 and BTB domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      E9Q3B1
      Conserved Domains (2) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl38908
      Location:374463
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    9. XM_006518382.4XP_006518445.1  RCC1 and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006518445.1

      UniProtKB/Swiss-Prot
      G1EE51, Q3TUA3, Q8BMG2, Q99LJ7
      UniProtKB/TrEMBL
      E9Q3B1
      Related
      ENSMUSP00000127397.2, ENSMUST00000171767.8
      Conserved Domains (3) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    10. XM_030247593.1XP_030103453.1  RCC1 and BTB domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      COG5184
      Location:13175
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:214330
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:327391
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    11. XM_036158373.1XP_036014266.1  RCC1 and BTB domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      G1EE51, Q3TUA3, Q8BMG2, Q99LJ7
      UniProtKB/TrEMBL
      E9Q3B1
      Conserved Domains (3) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    12. XM_036158376.1XP_036014269.1  RCC1 and BTB domain-containing protein 2 isoform X5

      Conserved Domains (2) summary
      COG5184
      Location:13175
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl38908
      Location:214303
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    13. XM_036158374.1XP_036014267.1  RCC1 and BTB domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      COG5184
      Location:13175
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:214330
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:327391
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    14. XM_030247591.2XP_030103451.1  RCC1 and BTB domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      E9Q3B1
      Related
      ENSMUSP00000128579.2, ENSMUST00000169513.8
      Conserved Domains (3) summary
      COG5184
      Location:83311
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:350466
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:463527
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    15. XM_006518385.4XP_006518448.1  RCC1 and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006518448.1

      UniProtKB/Swiss-Prot
      G1EE51, Q3TUA3, Q8BMG2, Q99LJ7
      UniProtKB/TrEMBL
      E9Q3B1
      Conserved Domains (3) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    16. XM_030247595.2XP_030103455.1  RCC1 and BTB domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      COG5184
      Location:13175
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:214330
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:327391
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    17. XM_006518383.4XP_006518446.1  RCC1 and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006518446.1

      UniProtKB/Swiss-Prot
      G1EE51, Q3TUA3, Q8BMG2, Q99LJ7
      UniProtKB/TrEMBL
      E9Q3B1
      Related
      ENSMUSP00000106577.4, ENSMUST00000110952.10
      Conserved Domains (3) summary
      COG5184
      Location:107335
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:374490
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:487551
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    18. XM_030247594.2XP_030103454.1  RCC1 and BTB domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      COG5184
      Location:13175
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd18354
      Location:214330
      BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
      cd18529
      Location:327391
      BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)