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    Wbp1l WW domain binding protein 1 like [ Mus musculus (house mouse) ]

    Gene ID: 226178, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Wbp1lprovided by MGI
    Official Full Name
    WW domain binding protein 1 likeprovided by MGI
    Primary source
    MGI:MGI:107577
    See related
    Ensembl:ENSMUSG00000047731 AllianceGenome:MGI:107577
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Opal1; D19Wsu162e
    Summary
    Enables ubiquitin protein ligase binding activity. Acts upstream of or within CXCL12-activated CXCR4 signaling pathway; hemopoiesis; and positive regulation of protein ubiquitination. Predicted to be located in membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and integumental system. Orthologous to human WBP1L (WW domain binding protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 63.4), liver adult (RPKM 60.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wbp1l in Genome Data Viewer
    Location:
    19 C3; 19 38.97 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46587545..46645828)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46599106..46657389)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E8752 Neighboring gene STARR-positive B cell enhancer mm9_chr19:46647489-46647790 Neighboring gene sideroflexin 2 Neighboring gene STARR-positive B cell enhancer ABC_E319 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46728226-46728566 Neighboring gene predicted gene, 36602 Neighboring gene Cyp17a1 promoter Neighboring gene cytochrome P450, family 17, subfamily a, polypeptide 1 Neighboring gene predicted gene, 41857

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WBP1L regulates hematopoietic stem cell function and T cell development. Krayem I, et al. Front Immunol, 2024. PMID 39555063, Free PMC Article
    2. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. Borna S, et al. J Cell Mol Med, 2020 Jan. PMID 31845480, Free PMC Article
    3. Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Kurogi S, et al. Sci Rep, 2017 Jan 20. PMID 28106071, Free PMC Article
    4. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.
      Title: Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31104

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CXCL12-activated CXCR4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within CXCL12-activated CXCR4 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WW domain binding protein 1-like
    Names
    outcome predictor in acute leukemia 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177812.1 → NP_001171283.1  WW domain binding protein 1-like isoform 1 precursor

      See identical proteins and their annotated locations for NP_001171283.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC156982, BC064096
      Consensus CDS
      CCDS50456.1
      UniProtKB/Swiss-Prot
      Q8BGW2
      Related
      ENSMUSP00000096975.5, ENSMUST00000099376.11
      Conserved Domains (1) summary
      pfam11669
      Location:59 → 160
      WBP-1; WW domain-binding protein 1

    2. NM_001177813.1 → NP_001171284.1  WW domain binding protein 1-like isoform 3

      See identical proteins and their annotated locations for NP_001171284.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (3) with a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK142695, BC058949, BC064096
      Consensus CDS
      CCDS50457.1
      UniProtKB/Swiss-Prot
      Q3TF48, Q3U3M2, Q6PD43, Q8BGW2, Q8R0W8
      Related
      ENSMUSP00000107486.5, ENSMUST00000111855.5
      Conserved Domains (1) summary
      pfam11669
      Location:22 → 123
      WBP-1; WW domain-binding protein 1

    3. NM_146099.3 → NP_666211.3  WW domain binding protein 1-like isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC156982, BC058949, BC064096, BY208074
      Consensus CDS
      CCDS29881.2
      UniProtKB/Swiss-Prot
      Q8BGW2
      Related
      ENSMUSP00000117929.3, ENSMUST00000138302.9
      Conserved Domains (1) summary
      pfam11669
      Location:43 → 144
      WBP-1; WW domain-binding protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46587545..46645828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGW2.1 GenPept UniProtKB/Swiss-Prot:Q8BGW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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