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    Epn2 epsin 2 [ Mus musculus (house mouse) ]

    Gene ID: 13855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Epn2provided by MGI
    Official Full Name
    epsin 2provided by MGI
    Primary source
    MGI:MGI:1333766
    See related
    Ensembl:ENSMUSG00000001036 AllianceGenome:MGI:1333766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ibp2; 9530051D10Rik
    Summary
    Predicted to enable clathrin binding activity and phospholipid binding activity. Acts upstream of or within Notch signaling pathway; embryonic organ development; and in utero embryonic development. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of clathrin coat of endocytic vesicle. Predicted to be active in endosome and plasma membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human EPN2 (epsin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 26.3), cerebellum adult (RPKM 19.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Epn2 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61406709..61470560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61515883..61579717, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6995 Neighboring gene mitogen-activated protein kinase 7 Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1 Neighboring gene STARR-seq mESC enhancer starr_29682 Neighboring gene STARR-positive B cell enhancer ABC_E3957 Neighboring gene STARR-positive B cell enhancer ABC_E3958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61483303-61483412 Neighboring gene GRB2-related adaptor protein Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 10 Neighboring gene family with sequence similarity 83, member G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epsin2 promotes polarity establishment and meiotic division through activating Cdc42 in mouse oocyte. Li L, et al. Oncotarget, 2016 Aug 9. PMID 27463009, Free PMC Article
    2. Motif mimetic of epsin perturbs tumor growth and metastasis. Dong Y, et al. J Clin Invest, 2015 Dec. PMID 26571402, Free PMC Article
    3. Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling. Dong Y, et al. Cells, 2021 Jul 29. PMID 34440686, Free PMC Article
    4. Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Kay BK, et al. Protein Sci, 1999 Feb. PMID 10048338, Free PMC Article
    5. Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development. Song K, et al. J Clin Invest, 2021 Jan 4. PMID 32960814, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling.
      Title: Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling.
    2. Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development.
      Title: Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development.
    3. Epsin-mediated degradation of IP3R1 fuels atherosclerosis.
      Title: Epsin-mediated degradation of IP3R1 fuels atherosclerosis.
    4. Diabetes attenuated VEGF-C-induced lymphangiogenesis in corneal micropocket and Matrigel plug assays in WT mice but not in mice with inducible lymphatic-specific deficiency of epsins 1 and 2 (LEC-iDKO).
      Title: Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes.
    5. our data identify Epsin2 as a novel player in regulating oocyte maturation, and demonstrate that Epsin2 promotes polarity establishment and meiotic division via activating Cdc42
      Title: Epsin2 promotes polarity establishment and meiotic division through activating Cdc42 in mouse oocyte.
    6. Epsins are required for Dishevelled stability and Wnt signalling activation in colon cancer development.
      Title: Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.
    7. epsins 1 and 2 have a critical role in the temporal and spatial regulation of VEGFR3 abundance and signaling in collecting lymphatic trunks during lymphatic valve formation
      Title: Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function.
    8. Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.
      Title: Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.
    9. Epsins function specifically to downregulate VEGFR2 by mediating activated VEGFR2 internalization and degradation and that genetic reduction of VEGFR2 level protects against excessive angiogenesis caused by epsin loss.
      Title: Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency.
    10. Loss of epsins 1 and 2 impaired endocytosis and degradation of VEGFR2, resulting in excessive VEGF signaling and compromised tumor vascular function.
      Title: Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic organ development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin coat of endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epsin-2
    Names
    EPS-15-interacting protein 2
    intersectin-EH-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252188.2 → NP_001239117.1  epsin-2 isoform 1

      See identical proteins and their annotated locations for NP_001239117.1

      Status: VALIDATED

      Source sequence(s)
      AK139234, AK160782, AL604029
      Consensus CDS
      CCDS56780.1
      UniProtKB/TrEMBL
      J3QNT7, Q5NCM5
      Related
      ENSMUSP00000136950.2, ENSMUST00000179936.8
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    2. NM_001252189.2 → NP_001239118.1  epsin-2 isoform 3

      See identical proteins and their annotated locations for NP_001239118.1

      Status: VALIDATED

      Source sequence(s)
      AK160782, AL604029
      Consensus CDS
      CCDS56779.1
      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Related
      ENSMUSP00000104353.2, ENSMUST00000108713.8
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    3. NM_001362585.1 → NP_001349514.1  epsin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL604029
      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    4. NM_001362586.1 → NP_001349515.1  epsin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL604029
      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    5. NM_001362587.1 → NP_001349516.1  epsin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL604029
      Consensus CDS
      CCDS24816.1
      UniProtKB/Swiss-Prot
      O70447, Q5NCM4, Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      Q5NCM6
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    6. NM_010148.4 → NP_034278.1  epsin-2 isoform 2

      See identical proteins and their annotated locations for NP_034278.1

      Status: VALIDATED

      Source sequence(s)
      AK160782, AL604029, CX123717
      Consensus CDS
      CCDS24816.1
      UniProtKB/Swiss-Prot
      O70447, Q5NCM4, Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      Q5NCM6
      Related
      ENSMUSP00000001063.9, ENSMUST00000001063.15
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61406709..61470560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532165.5 → XP_006532228.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532228.1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    2. XM_036156313.1 → XP_036012206.1  epsin-2 isoform X6

    3. XM_036156312.1 → XP_036012205.1  epsin-2 isoform X5

    4. XM_030245537.2 → XP_030101397.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    5. XM_030245533.2 → XP_030101393.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      O70447, Q5NCM4, Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      Q5NCM6
      Related
      ENSMUSP00000136553.2, ENSMUST00000178202.8
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    6. XM_006532171.5 → XP_006532234.1  epsin-2 isoform X2

      See identical proteins and their annotated locations for XP_006532234.1

      UniProtKB/TrEMBL
      J3QNT7, Q5NCM5
      Related
      ENSMUSP00000104352.2, ENSMUST00000108712.8
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    7. XM_030245539.2 → XP_030101399.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    8. XM_036156302.1 → XP_036012195.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      J3QNT7, Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    9. XM_030245538.2 → XP_030101398.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    10. XM_006532166.5 → XP_006532229.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532229.1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    11. XM_006532168.5 → XP_006532231.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532231.1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    12. XM_036156307.1 → XP_036012200.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    13. XM_030245531.2 → XP_030101391.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      O70447, Q5NCM4, Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      Q5NCM6
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    14. XM_030245528.2 → XP_030101388.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      J3QNT7, Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    15. XM_011248711.4 → XP_011247013.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_011247013.1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    16. XM_036156305.1 → XP_036012198.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    17. XM_036156303.1 → XP_036012196.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      O70447, Q5NCM4, Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      Q5NCM6
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    18. XM_006532167.5 → XP_006532230.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532230.1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    19. XM_036156308.1 → XP_036012201.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    20. XM_036156296.1 → XP_036012189.1  epsin-2 isoform X1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    21. XM_036156292.1 → XP_036012185.1  epsin-2 isoform X1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    22. XM_036156306.1 → XP_036012199.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    23. XM_036156299.1 → XP_036012192.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      J3QNT7, Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    24. XM_036156291.1 → XP_036012184.1  epsin-2 isoform X1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    25. XM_036156309.1 → XP_036012202.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Related
      ENSMUSP00000104351.2, ENSMUST00000108711.8
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    26. XM_030245534.2 → XP_030101394.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      O70447, Q5NCM4, Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      Q5NCM6
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    27. XM_036156301.1 → XP_036012194.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      J3QNT7, Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    28. XM_006532170.5 → XP_006532233.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532233.1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    29. XM_036156297.1 → XP_036012190.1  epsin-2 isoform X1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    30. XM_036156311.1 → XP_036012204.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    31. XM_036156300.1 → XP_036012193.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      J3QNT7, Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    32. XM_036156295.1 → XP_036012188.1  epsin-2 isoform X1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    33. XM_036156310.1 → XP_036012203.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    34. XM_036156293.1 → XP_036012186.1  epsin-2 isoform X1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    35. XM_030245540.2 → XP_030101400.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    36. XM_030245535.2 → XP_030101395.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      O70447, Q5NCM4, Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      Q5NCM6
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    37. XM_006532169.5 → XP_006532232.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_006532232.1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    38. XM_036156294.1 → XP_036012187.1  epsin-2 isoform X1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    39. XM_036156304.1 → XP_036012197.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      O70447, Q5NCM4, Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      Q5NCM6
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    40. XM_030245530.2 → XP_030101390.1  epsin-2 isoform X2

      UniProtKB/TrEMBL
      J3QNT7, Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    41. XM_011248713.4 → XP_011247015.1  epsin-2 isoform X1

      See identical proteins and their annotated locations for XP_011247015.1

      UniProtKB/TrEMBL
      Q5NCM5
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    42. XM_030245541.2 → XP_030101401.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    43. XM_030245532.2 → XP_030101392.1  epsin-2 isoform X3

      UniProtKB/Swiss-Prot
      O70447, Q5NCM4, Q8BZ85, Q8CHU3
      UniProtKB/TrEMBL
      Q5NCM6
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

    44. XM_030245536.1 → XP_030101396.1  epsin-2 isoform X4

      UniProtKB/TrEMBL
      Q5NCM6, Q5NCM7
      Conserved Domains (1) summary
      cd16990
      Location:19 → 141
      ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHU3.1 GenPept UniProtKB/Swiss-Prot:Q8CHU3

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