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    Rbbp4 retinoblastoma binding protein 4, chromatin remodeling factor [ Mus musculus (house mouse) ]

    Gene ID: 19646, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbbp4provided by MGI
    Official Full Name
    retinoblastoma binding protein 4, chromatin remodeling factorprovided by MGI
    Primary source
    MGI:MGI:1194912
    See related
    Ensembl:ENSMUSG00000057236 AllianceGenome:MGI:1194912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RBAP48; mRbAp48
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in DNA replication-dependent chromatin assembly; chromatin remodeling; and regulation of DNA-templated transcription. Located in nucleus. Part of ESC/E(Z) complex and NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; gonad; hemolymphoid system gland; and retina nuclear layer. Orthologous to human RBBP4 (RB binding protein 4, chromatin remodeling factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 70.9), liver E14 (RPKM 42.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Rbbp4 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.26 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129200893..129229163, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129307100..129335370, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3517 Neighboring gene STARR-seq mESC enhancer starr_11478 Neighboring gene tyrosyl-tRNA synthetase 1 Neighboring gene STARR-seq mESC enhancer starr_11480 Neighboring gene NHS like 3 Neighboring gene STARR-seq mESC enhancer starr_11482 Neighboring gene predicted gene 12976 Neighboring gene STARR-positive B cell enhancer ABC_E7991 Neighboring gene syncoilin Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129012802-129012911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129013051-129013391 Neighboring gene zinc finger and BTB domain containing 8 opposite strand Neighboring gene zinc finger and BTB domain containing 8a Neighboring gene STARR-seq mESC enhancer starr_11489

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ATP-dependent activity, acting on DNA  
    contributes_to ATP-dependent activity, acting on DNA  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables histone binding  
    enables histone binding  
    enables histone binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication  
    involved_in DNA replication-dependent chromatin assembly  
    involved_in DNA replication-dependent chromatin assembly  
    involved_in brain development PubMed 
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    acts_upstream_of_or_within chromatin remodeling PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of stem cell population maintenance PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in nucleosome assembly  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of stem cell population maintenance PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of cell fate specification PubMed 
    involved_in regulation of stem cell differentiation PubMed 
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    part_of ATPase complex  
    part_of CAF-1 complex  
    part_of CAF-1 complex  
    part_of ESC/E(Z) complex  
    part_of ESC/E(Z) complex PubMed 
    part_of ESC/E(Z) complex  
    part_of NURF complex  
    part_of NuRD complex  
    part_of NuRD complex PubMed 
    part_of NuRD complex  
    part_of NuRD complex PubMed 
    part_of Sin3-type complex PubMed 
    located_in chromatin  
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    located_in cytosol  
    located_in cytosol  
    part_of histone deacetylase complex  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in nucleus PubMed 
    part_of protein-containing complex  
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    histone-binding protein RBBP4
    Names
    CAF-1 p48 subunit
    CAF-1 subunit C
    CAF-I 48 kDa subunit
    CAF-I p48
    RBBP-4
    chromatin assembly factor 1 subunit C
    chromatin assembly factor I p48 subunit
    nucleosome-remodeling factor subunit RBAP48
    retinoblastoma-binding protein 4
    retinoblastoma-binding protein p48

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009030.3NP_033056.2  histone-binding protein RBBP4

      See identical proteins and their annotated locations for NP_033056.2

      Status: VALIDATED

      Source sequence(s)
      AL607123
      Consensus CDS
      CCDS18688.1
      UniProtKB/Swiss-Prot
      A2A875, Q60972
      Related
      ENSMUSP00000099658.4, ENSMUST00000102598.4
      Conserved Domains (3) summary
      sd00039
      Location:128175
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:1988
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:122403
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129200893..129229163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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