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    Zfp362 zinc finger protein 362 [ Mus musculus (house mouse) ]

    Gene ID: 230761, updated on 16-Dec-2024

    Summary

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    Official Symbol
    Zfp362provided by MGI
    Official Full Name
    zinc finger protein 362provided by MGI
    Primary source
    MGI:MGI:2652839
    See related
    Ensembl:ENSMUSG00000028799 AllianceGenome:MGI:2652839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to human ZNF362 (zinc finger protein 362). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 27.1), ovary adult (RPKM 26.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp362 in Genome Data Viewer
    Location:
    4 D2.2; 4 62.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128666881..128700118, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (128773085..128806112, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene polyhomeotic 2 Neighboring gene STARR-seq mESC enhancer starr_11460 Neighboring gene predicted gene, 33712 Neighboring gene STARR-positive B cell enhancer ABC_E9595 Neighboring gene alpha 1,3-galactosyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3514 Neighboring gene STARR-seq mESC enhancer starr_11464 Neighboring gene predicted gene, 52679 Neighboring gene STARR-positive B cell enhancer ABC_E6220 Neighboring gene STARR-seq mESC enhancer starr_11466 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 33814

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation. Herppich S, et al. Eur J Immunol, 2023 Oct. PMID 37366299
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation.
      Title: Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 362

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081098.2 → NP_001074567.1  zinc finger protein 362 isoform a

      See identical proteins and their annotated locations for NP_001074567.1

      Status: VALIDATED

      Source sequence(s)
      AL611983
      Consensus CDS
      CCDS38884.1
      UniProtKB/TrEMBL
      B1ASA5, E9QA68
      Related
      ENSMUSP00000101686.3, ENSMUST00000106072.9
      Conserved Domains (5) summary
      COG5189
      Location:305 → 357
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PRK14971
      Location:27 → 131
      PRK14971; DNA polymerase III subunit gamma/tau
      sd00017
      Location:255 → 275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:253 → 275
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:267 → 292
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001419423.1 → NP_001406352.1  zinc finger protein 362 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL611983
      UniProtKB/TrEMBL
      B1ASA5, E9QA68

    3. NM_001419424.1 → NP_001406353.1  zinc finger protein 362 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL611983
      UniProtKB/TrEMBL
      B1ASA5, E9QA68

    4. NM_001419425.1 → NP_001406354.1  zinc finger protein 362 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL611983
      UniProtKB/TrEMBL
      E9QA68
      Related
      ENSMUSP00000128499.2, ENSMUST00000170934.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      128666881..128700118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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