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    PDX3 pyridoxamine-phosphate oxidase PDX3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PDX3
    Official Full Name
    pyridoxamine-phosphate oxidase PDX3
    Primary source
    SGD:S000000239
    Locus tag
    YBR035C
    See related
    AllianceGenome:SGD:S000000239; FungiDB:YBR035C; VEuPathDB:YBR035C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables FMN binding activity and pyridoxamine phosphate oxidase activity. Predicted to be involved in pyridoxal 5'-phosphate salvage. Located in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PDX3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (306269..306955, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Eds1p Neighboring gene protein-arginine omega-N methyltransferase HMT1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase. Loubbardi A, et al. J Bacteriol, 1995 Apr. PMID 7896706, Free PMC Article
    2. The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene. Smits PH, et al. Yeast, 1994 Apr. PMID 8091864
    3. Identification of a pyridoxine (pyridoxamine) 5'-phosphate oxidase from Arabidopsis thaliana. Sang Y, et al. FEBS Lett, 2007 Feb 6. PMID 17224143
    4. Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Marbaix AY, et al. Biochem J, 2019 Oct 30. PMID 31657440
    5. Evolution of vitamin B6 (pyridoxine) metabolism by gain and loss of genes. Tanaka T, et al. Mol Biol Evol, 2005 Feb. PMID 15483325

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxamine phosphate oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxamine phosphate oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxamine phosphate oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxamine phosphate oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in organic hydroxy compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridoxal 5'-phosphate salvage IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vitamin B6 metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyridoxamine-phosphate oxidase PDX3
    NP_009591.1
    • Pyridoxine (pyridoxamine) phosphate oxidase; has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      306269..306955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178383.1 → NP_009591.1  TPA: pyridoxamine-phosphate oxidase PDX3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009591.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ35, P38075
      UniProtKB/TrEMBL
      A6ZKX9, B3LNB0, B5VE01, C7GXX7, D3UED1, G2W940, N1P890
      Conserved Domains (1) summary
      COG0259
      Location:13 → 228
      PdxH; Pyridoxine/pyridoxamine 5'-phosphate oxidase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38075.1

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