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    AAC3 ADP/ATP carrier protein AAC3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AAC3
    Official Full Name
    ADP/ATP carrier protein AAC3
    Primary source
    SGD:S000000289
    Locus tag
    YBR085W
    See related
    AllianceGenome:SGD:S000000289; FungiDB:YBR085W; VEuPathDB:YBR085W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ANC3
    Summary
    Predicted to enable ATP:ADP antiporter activity. Involved in anaerobic respiration and heme transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to several human genes including SLC25A4 (solute carrier family 25 member 4) and SLC25A5 (solute carrier family 25 member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AAC3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (415983..416906)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1 Neighboring gene ribosomal 60S subunit protein L19A Neighboring gene uncharacterized protein Neighboring gene Ist2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing the interactions of carboxy-atractyloside and atractyloside with the yeast mitochondrial ADP/ATP carrier. Kedrov A, et al. Structure, 2010 Jan 13. PMID 20152151
    2. Lipid, detergent, and Coomassie Blue G-250 affect the migration of small membrane proteins in blue native gels: mitochondrial carriers migrate as monomers not dimers. Crichton PG, et al. J Biol Chem, 2013 Jul 26. PMID 23744064, Free PMC Article
    3. Substrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion. Brüschweiler S, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167881, Free PMC Article
    4. Transcriptional control of AAC3 gene encoding mitochondrial ADP/ATP translocator in Saccharomyces cerevisiae by oxygen, heme and ROX1 factor. Sabová L, et al. Eur J Biochem, 1993 Apr 1. PMID 8477727
    5. Yeast mitochondrial ADP/ATP carriers are monomeric in detergents. Bamber L, et al. Proc Natl Acad Sci U S A, 2006 Oct 31. PMID 17056710, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that ADP/ATP carrier protein AAC3 is predominantly in the cytosol-facing open state and converts to a sparsely populated state in an asymmetric manner despite its three-fold structural symmetry.
      Title: Substrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion.
    2. Data indicate that the apparent mass of AAC3 varies in a detergent- and lipid-dependent manner in gel electrophoresis.
      Title: Lipid, detergent, and Coomassie Blue G-250 affect the migration of small membrane proteins in blue native gels: mitochondrial carriers migrate as monomers not dimers.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP:ADP antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP:ADP antiporter activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaerobic respiration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heme transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial ADP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial ATP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP/ATP carrier protein AAC3
    NP_009642.3
    • Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      415983..416906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178433.3 → NP_009642.3  TPA: ADP/ATP carrier protein AAC3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009642.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ85, P18238
      UniProtKB/TrEMBL
      A6ZL32, B3LN66, B5VE49, C7GJS5, D3UEH9, G2W992, N1P838
      Conserved Domains (1) summary
      PTZ00169
      Location:6 → 301
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18238.1

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