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    Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 56543, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnd3provided by MGI
    Official Full Name
    potassium voltage-gated channel, Shal-related family, member 3provided by MGI
    Primary source
    MGI:MGI:1928743
    See related
    Ensembl:ENSMUSG00000040896 AllianceGenome:MGI:1928743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kncd3; Kv4.3
    Summary
    Predicted to enable A-type (transient outward) potassium channel activity and transmembrane transporter binding activity. Predicted to contribute to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Predicted to be involved in several processes, including cellular response to BMP stimulus; potassium ion transmembrane transport; and regulation of heart rate by cardiac conduction. Located in membrane. Part of voltage-gated potassium channel complex. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Is expressed in heart and heart ventricle. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 8.1), cerebellum adult (RPKM 6.3) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcnd3 in Genome Data Viewer
    Location:
    3 F2.2; 3 46.32 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105359206..105581318)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105451890..105674002)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104936010-104936231 Neighboring gene predicted gene, 40118 Neighboring gene STARR-seq mESC enhancer starr_08631 Neighboring gene predicted gene, 34837 Neighboring gene STARR-seq mESC enhancer starr_08632 Neighboring gene STARR-seq mESC enhancer starr_08634 Neighboring gene potassium voltage-gated channel, Shal-related family, member 3, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E6095 Neighboring gene STARR-positive B cell enhancer ABC_E8804 Neighboring gene STARR-positive B cell enhancer ABC_E2091 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:105507469-105507578 Neighboring gene DEAD box helicase 20 Neighboring gene inka box actin regulator 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in action potential  
    involved_in cellular response to BMP stimulus  
    involved_in chemical synaptic transmission PubMed 
    involved_in membrane repolarization  
    involved_in membrane repolarization PubMed 
    involved_in membrane repolarization during cardiac muscle cell action potential  
    involved_in membrane repolarization during ventricular cardiac muscle cell action potential  
    involved_in muscle contraction PubMed 
    involved_in potassium ion export across plasma membrane  
    involved_in potassium ion export across plasma membrane  
    involved_in potassium ion export across plasma membrane PubMed 
    involved_in potassium ion import across plasma membrane  
    involved_in protein homooligomerization  
    involved_in protein tetramerization  
    involved_in regulation of heart contraction PubMed 
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in ventricular cardiac muscle cell membrane repolarization  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    part_of Kv4.3-KChIP1 channel complex  
    located_in caveola  
    located_in dendrite  
    located_in dendrite  
    is_active_in dendritic spine  
    located_in membrane PubMed 
    is_active_in neuronal cell body  
    located_in neuronal cell body  
    located_in perinuclear endoplasmic reticulum  
    is_active_in postsynaptic membrane  
    is_active_in postsynaptic specialization membrane PubMed 
    part_of potassium channel complex  
    located_in sarcolemma  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex PubMed 
    part_of voltage-gated potassium channel complex  

    General protein information

    Preferred Names
    A-type voltage-gated potassium channel KCND3; potassium voltage-gated channel subfamily D member 3
    Names
    potassium channel Kv4.3L
    potassium channel Kv4.3M
    voltage-gated potassium channel subunit Kv4.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039347.2NP_001034436.1  A-type voltage-gated potassium channel KCND3 isoform 1

      See identical proteins and their annotated locations for NP_001034436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC123041, AC123847, AC139316
      Consensus CDS
      CCDS17708.1
      UniProtKB/TrEMBL
      Q3UH54
      Related
      ENSMUSP00000096357.4, ENSMUST00000098761.10
      Conserved Domains (6) summary
      smart00225
      Location:42139
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:217412
      Ion_trans; Ion transport protein
      pfam02214
      Location:42131
      BTB_2; BTB/POZ domain
      pfam07885
      Location:328408
      Ion_trans_2; Ion channel
      pfam11601
      Location:328
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:442544
      DUF3399; Domain of unknown function (DUF3399)
    2. NM_019931.2NP_064315.1  A-type voltage-gated potassium channel KCND3 isoform 2

      See identical proteins and their annotated locations for NP_064315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC123041, AC123847, AC139316
      Consensus CDS
      CCDS17709.1
      UniProtKB/Swiss-Prot
      Q8CC44, Q9Z0V0, Q9Z0V1
      UniProtKB/TrEMBL
      B2RUE0
      Related
      ENSMUSP00000078169.5, ENSMUST00000079169.5
      Conserved Domains (3) summary
      cd18419
      Location:6143
      BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)
      pfam00520
      Location:182412
      Ion_trans; Ion transport protein
      pfam11879
      Location:442563
      DUF3399; Domain of unknown function (DUF3399)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      105359206..105581318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163174.1XP_036019067.1  potassium voltage-gated channel subfamily D member 3 isoform X2

      Conserved Domains (2) summary
      cd18419
      Location:6143
      BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)
      pfam00520
      Location:186369
      Ion_trans; Ion transport protein
    2. XM_030252699.2XP_030108559.1  potassium voltage-gated channel subfamily D member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8CC44, Q9Z0V0, Q9Z0V1
      UniProtKB/TrEMBL
      B2RUE0
      Conserved Domains (3) summary
      cd18419
      Location:6143
      BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)
      pfam00520
      Location:182412
      Ion_trans; Ion transport protein
      pfam11879
      Location:442563
      DUF3399; Domain of unknown function (DUF3399)
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