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    Umps uridine monophosphate synthetase [ Mus musculus (house mouse) ]

    Gene ID: 22247, updated on 9-Dec-2024

    Summary

    Official Symbol
    Umpsprovided by MGI
    Official Full Name
    uridine monophosphate synthetaseprovided by MGI
    Primary source
    MGI:MGI:1298388
    See related
    Ensembl:ENSMUSG00000022814 AllianceGenome:MGI:1298388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700095D23Rik
    Summary
    Enables orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; limb bud; metanephros; pancreas; and surface ectoderm. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 16.6), liver E14.5 (RPKM 14.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Umps in Genome Data Viewer
    Location:
    16 B3; 16 24.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33775152..33787408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33954782..33967038, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40715 Neighboring gene STARR-seq mESC enhancer starr_40716 Neighboring gene STARR-seq mESC enhancer starr_40719 Neighboring gene predicted gene, 34967 Neighboring gene integrin beta 5 Neighboring gene STARR-positive B cell enhancer ABC_E8630 Neighboring gene STARR-seq mESC enhancer starr_40721 Neighboring gene VISTA enhancer mm268 Neighboring gene kalirin, RhoGEF kinase Neighboring gene STARR-seq mESC enhancer starr_40723 Neighboring gene STARR-seq mESC enhancer starr_40724 Neighboring gene predicted gene, 41448 Neighboring gene STARR-seq mESC enhancer starr_40725 Neighboring gene ropporin, rhophilin associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    uridine 5'-monophosphate synthase
    Names
    UMP synthase
    NP_001335016.1
    NP_033497.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348087.1NP_001335016.1  uridine 5'-monophosphate synthase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC165079, AK035997
      Conserved Domains (1) summary
      pfam00215
      Location:74288
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
    2. NM_009471.3NP_033497.1  uridine 5'-monophosphate synthase isoform 1

      See identical proteins and their annotated locations for NP_033497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC165079, AK035821, BM219105
      Consensus CDS
      CCDS28136.1
      UniProtKB/Swiss-Prot
      P13439, Q99L26
      UniProtKB/TrEMBL
      Q3TVV7, Q544K9
      Related
      ENSMUSP00000023510.7, ENSMUST00000023510.7
      Conserved Domains (2) summary
      pfam00215
      Location:252466
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
      cl00309
      Location:9204
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      33775152..33787408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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