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    Tmem196 transmembrane protein 196 [ Mus musculus (house mouse) ]

    Gene ID: 217951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem196provided by MGI
    Official Full Name
    transmembrane protein 196provided by MGI
    Primary source
    MGI:MGI:2685374
    See related
    Ensembl:ENSMUSG00000048004 AllianceGenome:MGI:2685374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm528
    Summary
    Predicted to be involved in several processes, including negative regulation of cell growth; negative regulation of cell migration; and positive regulation of apoptotic process. Predicted to be located in cytoplasm. Is expressed in brain. Orthologous to human TMEM196 (transmembrane protein 196). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 2.8), cortex adult (RPKM 2.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem196 in Genome Data Viewer
    Location:
    12 F2; 12 63.86 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (119909422..119984981)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (119946127..120021242)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene NOP2 nucleolar protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_33458 Neighboring gene STARR-seq mESC enhancer starr_33459 Neighboring gene STARR-seq mESC enhancer starr_33460 Neighboring gene STARR-seq mESC enhancer starr_33461 Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33462 Neighboring gene STARR-seq mESC enhancer starr_33463

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TMEM196 inhibits lung cancer metastasis by regulating the Wnt/β-catenin signaling pathway. Chen J, et al. J Cancer Res Clin Oncol, 2023 Feb. PMID 36355209
    2. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM196 inhibits lung cancer metastasis by regulating the Wnt/beta-catenin signaling pathway.
      Title: TMEM196 inhibits lung cancer metastasis by regulating the Wnt/β-catenin signaling pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 196

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160385.3 → NP_001153857.1  transmembrane protein 196 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC164110, AC225445
      Consensus CDS
      CCDS49200.1
      UniProtKB/Swiss-Prot
      D3YWQ9
      Related
      ENSMUSP00000054994.8, ENSMUST00000058644.15

    2. NM_001294146.2 → NP_001281075.1  transmembrane protein 196 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC164110, AC225445
      Consensus CDS
      CCDS79159.1
      UniProtKB/TrEMBL
      V9GX04
      Related
      ENSMUSP00000138921.2, ENSMUST00000183694.8

    3. NM_001294154.2 → NP_001281083.1  transmembrane protein 196 isoform 3

      See identical proteins and their annotated locations for NP_001281083.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and contains an alternate exon, which results in a frameshift, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC164110, AC225445
      UniProtKB/TrEMBL
      V9GX16
      Related
      ENSMUSP00000138937.2, ENSMUST00000184820.8

    4. NM_001379146.1 → NP_001366075.1  transmembrane protein 196 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC164110, AC225445
      UniProtKB/TrEMBL
      V9GX78
      Related
      ENSMUSP00000139022.2, ENSMUST00000184069.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      119909422..119984981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157376.1 → XP_036013269.1  transmembrane protein 196 isoform X1

      UniProtKB/TrEMBL
      V9GX16
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3YWQ9.2 GenPept UniProtKB/Swiss-Prot:D3YWQ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials