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    Tmem38b transmembrane protein 38B [ Mus musculus (house mouse) ]

    Gene ID: 52076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem38bprovided by MGI
    Official Full Name
    transmembrane protein 38Bprovided by MGI
    Primary source
    MGI:MGI:1098718
    See related
    Ensembl:ENSMUSG00000028420 AllianceGenome:MGI:1098718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mg33b; TRIC-B; D4Ertd89e; 1600017F22Rik
    Summary
    Predicted to enable potassium channel activity. Acts upstream of or within several processes, including cellular response to caffeine; lung development; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 14. Orthologous to human TMEM38B (transmembrane protein 38B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.5), liver adult (RPKM 7.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem38b in Genome Data Viewer
    Location:
    4 B2; 4 28.76 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (53825988..53862019)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (53825988..53862019)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10245 Neighboring gene ribosomal protein S15A, pseudogene 8 Neighboring gene T cell acute lymphocytic leukemia 2 Neighboring gene STARR-seq mESC enhancer starr_10246 Neighboring gene STARR-seq mESC enhancer starr_10248 Neighboring gene STARR-seq mESC enhancer starr_10250 Neighboring gene nuclear encoded rRNA 5S 185 Neighboring gene predicted gene 12468 Neighboring gene predicted gene, 54229 Neighboring gene predicted gene, 23745

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice. Ichimura A, et al. Cell Death Dis, 2023 Dec 20. PMID 38123563, Free PMC Article
    2. TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model. Venturi E, et al. Pflugers Arch, 2013 Aug. PMID 23467973, Free PMC Article
    3. Subconductance gating and voltage sensitivity of sarcoplasmic reticulum K(+) channels: a modeling approach. Matyjaszkiewicz A, et al. Biophys J, 2015 Jul 21. PMID 26200862, Free PMC Article
    4. TRIC-B Mutations Causing Osteogenesis Imperfecta. Ichimura A, et al. Biol Pharm Bull, 2016. PMID 27803445
    5. Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study. Jovanovic M, et al. Matrix Biol, 2023 Aug. PMID 37348683, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice.
      Title: Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice.
    2. Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study.
      Title: Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study.
    3. CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfecta.
      Title: CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfecta.
    4. The role of TRIC-A and TRIC-B channels in skeletal muscle sarcoplasmic reticulum channels is reported.
      Title: Enhanced activity of multiple TRIC-B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents.
    5. TRIC-B function is essential to support the production and release of large amounts of collagen by osteoblasts, which is necessary for bone mineralization
      Title: Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.
    6. This mini-review focuses on the essential role of TRIC-B channels in bone ossification.
      Title: TRIC-B Mutations Causing Osteogenesis Imperfecta.
    7. Study found that a simplified, linear, six-state gating model best encompasses the complexity of the subconductance gating behavior of TRIC-B channels
      Title: Subconductance gating and voltage sensitivity of sarcoplasmic reticulum K(+) channels: a modeling approach.
    8. Rapid transitions between TRIC-B sub-conductance states prevented development of reliable gating models.
      Title: TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model.
    9. TRIC-A and TRIC-B seem to have differential functions in Ca(2+) signaling in excitable and nonexcitable cells.
      Title: Trimeric intracellular cation channels and sarcoplasmic/endoplasmic reticulum calcium homeostasis.
    10. TRIC-B-knockout neonates were cyanotic owing to respiratory failure and died shortly after birth. In mutant neonates, the deflated lungs exhibited severe histological defects, and alveolar type II epithelial cells displayed ultrastructural abnormalities.
      Title: Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to caffeine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endoplasmic reticulum organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular matrix constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol by endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within secretion by lung epithelial cell involved in lung growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trimeric intracellular cation channel type B
    Names
    Mitsugumin33B
    TRICB
    mitsugumin-33B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028053.2 → NP_082329.1  trimeric intracellular cation channel type B

      See identical proteins and their annotated locations for NP_082329.1

      Status: VALIDATED

      Source sequence(s)
      AK005479, AK136131, AK150377, BY138283
      Consensus CDS
      CCDS18193.1
      UniProtKB/Swiss-Prot
      A2AQG4, Q3U6M4, Q3UBM6, Q3UWS8, Q9DAV9
      Related
      ENSMUSP00000030127.7, ENSMUST00000030127.13
      Conserved Domains (1) summary
      pfam05197
      Location:39 → 222
      TRIC; TRIC channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      53825988..53862019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538083.2 → XP_006538146.1  trimeric intracellular cation channel type B isoform X1

      Conserved Domains (1) summary
      pfam05197
      Location:1 → 106
      TRIC; TRIC channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAV9.1 GenPept UniProtKB/Swiss-Prot:Q9DAV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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