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    Anxa4 annexin A4 [ Mus musculus (house mouse) ]

    Gene ID: 11746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anxa4provided by MGI
    Official Full Name
    annexin A4provided by MGI
    Primary source
    MGI:MGI:88030
    See related
    Ensembl:ENSMUSG00000029994 AllianceGenome:MGI:88030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AIV; Anx4; Xanx-4
    Summary
    Predicted to enable several functions, including NF-kappaB binding activity; calcium-dependent protein binding activity; and phospholipid binding activity. Acts upstream of or within Notch signaling pathway. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; chordamesoderm; inner ear; and lung. Orthologous to human ANXA4 (annexin A4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 135.1), small intestine adult (RPKM 70.5) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Anxa4 in Genome Data Viewer
    Location:
    6 D1; 6 37.75 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86713822..86770616, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86736840..86793634, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86634487-86634670 Neighboring gene small nuclear ribonucleoprotein 27 (U4/U6.U5) Neighboring gene germ cell-less, spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E3661 Neighboring gene STARR-seq mESC enhancer starr_16540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86774247-86774356 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6451 Neighboring gene AP2 associated kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9670 Neighboring gene STARR-positive B cell enhancer ABC_E8113 Neighboring gene STARR-seq mESC enhancer starr_16545 Neighboring gene NFU1 iron-sulfur cluster scaffold

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Studies on localization and function of annexin A4a within urinary bladder epithelium using a mouse knockout model. Hill WG, et al. Am J Physiol Renal Physiol, 2008 Apr. PMID 18256316, Free PMC Article
    2. Intron disruption of the annexin IV gene reveals novel transcripts. Li B, et al. J Biol Chem, 2003 Oct 31. PMID 12912993
    3. Annexin A4 N-terminal peptide inhibits adenylyl cyclase 5 and limits β-adrenoceptor-mediated prolongation of cardiac action potential. Heinick A, et al. FASEB J, 2020 Aug. PMID 32579290
    4. Cloning and functional activity of a novel truncated form of annexin IV in mouse macrophages. Sable CL, et al. Biochem Biophys Res Commun, 1999 Apr 29. PMID 10222253
    5. Chromosomal mapping of the human annexin IV (ANX4) gene. Tait JF, et al. Genomics, 1992 Feb. PMID 1346776

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANXA4 Activates JAK-STAT3 Signaling by Interacting with ANXA1 in Basal-Like Breast Cancer.
      Title: ANXA4 Activates JAK-STAT3 Signaling by Interacting with ANXA1 in Basal-Like Breast Cancer.
    2. Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification
      Title: Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification.
    3. these results suggest that AnxA4 is a novel direct negative regulator of AC5, adding a new facet to the functions of annexins.
      Title: Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.
    4. Fhit delocalizes annexin A4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.
      Title: Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.
    5. NME1 controls annexin IV and EF-1Balpha amounts by post-translational mechanisms.
      Title: Proteomic analysis of NME1/NDPK A null mouse liver: evidence for a post-translational regulation of annexin IV and EF-1Bα.
    6. analysis of intron disruptions in the annexin IV gene that produce novel transcripts
      Title: Intron disruption of the annexin IV gene reveals novel transcripts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kidney development ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in zymogen granule membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    annexin A4
    Names
    annexin IV
    annexin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331120.1 → NP_001318049.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662, AK132293, AK150486
      Consensus CDS
      CCDS39543.1
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Conserved Domains (1) summary
      pfam00191
      Location:249 → 314
      Annexin

    2. NM_001409435.1 → NP_001396364.1  annexin A4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/TrEMBL
      Q7TMN7

    3. NM_001409436.1 → NP_001396365.1  annexin A4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/TrEMBL
      Q7TMN7

    4. NM_001409437.1 → NP_001396366.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Related
      ENSMUSP00000145421.2, ENSMUST00000204441.3

    5. NM_001409438.1 → NP_001396367.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7

    6. NM_001409439.1 → NP_001396368.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Related
      ENSMUSP00000144961.2, ENSMUST00000204398.2

    7. NM_001409442.1 → NP_001396371.1  annexin A4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Related
      ENSMUSP00000109305.2, ENSMUST00000113675.8

    8. NM_001409443.1 → NP_001396372.1  annexin A4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/TrEMBL
      D3Z0S1
      Related
      ENSMUSP00000115346.2, ENSMUST00000123732.4

    9. NM_001409444.1 → NP_001396373.1  annexin A4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/TrEMBL
      Q7TMN7

    10. NM_001409445.1 → NP_001396374.1  annexin A4 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      UniProtKB/TrEMBL
      A0A0N4SV57, Q8BSL2

    11. NM_001409446.1 → NP_001396375.1  annexin A4 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/TrEMBL
      A0A0N4SV57, Q8BSL2
      Related
      ENSMUST00000129772.2

    12. NM_001409447.1 → NP_001396376.1  annexin A4 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC158662
      UniProtKB/TrEMBL
      Q9R0V2

    13. NM_001409448.1 → NP_001396377.1  annexin A4 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662

    14. NM_013471.3 → NP_038499.2  annexin A4 isoform a

      See identical proteins and their annotated locations for NP_038499.2

      Status: VALIDATED

      Source sequence(s)
      AC157099, AC158662
      Consensus CDS
      CCDS39543.1
      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Related
      ENSMUSP00000001187.9, ENSMUST00000001187.15
      Conserved Domains (1) summary
      pfam00191
      Location:249 → 314
      Annexin

    RNA

    1. NR_176838.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158662

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      86713822..86770616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165761.1 → XP_036021654.1  annexin A4 isoform X1

      UniProtKB/Swiss-Prot
      P97429, Q3UCL0
      UniProtKB/TrEMBL
      Q7TMN7
      Conserved Domains (1) summary
      pfam00191
      Location:249 → 314
      Annexin

    2. XM_011241158.3 → XP_011239460.1  annexin A4 isoform X2

      UniProtKB/TrEMBL
      Q9R0V2, S4R1F2
      Related
      ENSMUSP00000138194.2, ENSMUST00000127152.9
      Conserved Domains (1) summary
      pfam00191
      Location:90 → 155
      Annexin

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001409440.1: Suppressed sequence

      Description
      NM_001409440.1: This RefSeq was removed because it was redundant with NM_001409437.1.

    2. NM_001409441.1: Suppressed sequence

      Description
      NM_001409441.1: This RefSeq was removed because it was redundant with NM_001409439.1.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97429.4 GenPept UniProtKB/Swiss-Prot:P97429

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools