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    Sparc secreted acidic cysteine rich glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 20692, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sparcprovided by MGI
    Official Full Name
    secreted acidic cysteine rich glycoproteinprovided by MGI
    Primary source
    MGI:MGI:98373
    See related
    Ensembl:ENSMUSG00000018593 AllianceGenome:MGI:98373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ON; BM-40
    Summary
    Enables calcium ion binding activity and extracellular matrix binding activity. Acts upstream of or within several processes, including bone development; cellular response to growth factor stimulus; and pigmentation. Located in extracellular matrix and extracellular space. Is expressed in several structures, including brain; egg cylinder; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 1043.9), bladder adult (RPKM 893.4) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Sparc in Genome Data Viewer
    Location:
    11 B1.3; 11 33.04 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55284985..55310906, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55394159..55420080, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 2 Neighboring gene STARR-seq mESC enhancer starr_29533 Neighboring gene predicted gene, 31842 Neighboring gene STARR-seq mESC enhancer starr_29535 Neighboring gene STARR-seq mESC enhancer starr_29537 Neighboring gene STARR-seq mESC enhancer starr_29542 Neighboring gene STARR-seq mESC enhancer starr_29544 Neighboring gene antioxidant 1 copper chaperone Neighboring gene predicted gene 12235

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables calcium ion binding  
    enables collagen binding  
    enables collagen binding  
    enables extracellular matrix binding  
    enables extracellular matrix binding PubMed 
    enables extracellular matrix structural constituent PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in basement membrane  
    located_in cell surface  
    located_in collagen-containing extracellular matrix PubMed 
    located_in cytoplasm  
    located_in extracellular matrix PubMed 
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in glutamatergic synapse  
    located_in intracellular membrane-bounded organelle  
    located_in nuclear matrix  
    located_in platelet alpha granule  
    located_in platelet alpha granule membrane  
    is_active_in synapse  
    located_in vesicle  

    General protein information

    Preferred Names
    SPARC
    Names
    basement-membrane protein 40
    osteonectin
    secreted protein acidic and rich in cysteine

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290817.1NP_001277746.1  SPARC isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AA798908, AK148670, AK161229, BB857564, BE655213, BY781653, CJ132527
      Consensus CDS
      CCDS70189.1
      UniProtKB/TrEMBL
      Q3TXI6, Q5NCU4
      Related
      ENSMUSP00000104486.2, ENSMUST00000108858.8
      Conserved Domains (2) summary
      cd01328
      Location:69150
      FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
      cd16235
      Location:153292
      EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)
    2. NM_009242.5NP_033268.1  SPARC precursor

      See identical proteins and their annotated locations for NP_033268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA798908, AK161229, BB857564, BE655213, BY781653, CJ132527
      Consensus CDS
      CCDS24712.1
      UniProtKB/Swiss-Prot
      P07214
      UniProtKB/TrEMBL
      Q3TXI6, Q5NCU5
      Related
      ENSMUSP00000018737.7, ENSMUST00000018737.13
      Conserved Domains (2) summary
      cd01328
      Location:70151
      FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
      cd16235
      Location:154293
      EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      55284985..55310906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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