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    Hspa4 heat shock protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 15525, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hspa4provided by MGI
    Official Full Name
    heat shock protein 4provided by MGI
    Primary source
    MGI:MGI:1342292
    See related
    Ensembl:ENSMUSG00000020361 AllianceGenome:MGI:1342292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    70kDa; APG-2; Hsp110; Hsp70RY; mKIAA4025
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and adenyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; negative regulation of macromolecule metabolic process; and protein insertion into mitochondrial outer membrane. Predicted to be located in extracellular exosome and lipid droplet. Predicted to be active in cytosol and nucleus. Is expressed in cerebral cortex and genitourinary system. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 44.3), adrenal adult (RPKM 30.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hspa4 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.91 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53150641..53191306, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53259814..53300479, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene follistatin-like 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52942269-52942487 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52946269-52946452 Neighboring gene predicted gene 11186 Neighboring gene STARR-seq mESC enhancer starr_29473 Neighboring gene STARR-seq mESC enhancer starr_29474 Neighboring gene TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_29475 Neighboring gene STARR-seq mESC enhancer starr_29476 Neighboring gene STARR-positive B cell enhancer ABC_E2987 Neighboring gene STARR-seq mESC enhancer starr_29480 Neighboring gene predicted gene, 30525 Neighboring gene zinc finger, CCHC domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    General gene information

    Clone Names

    • KIAA4025

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP-dependent protein folding chaperone  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables adenyl-nucleotide exchange factor activity  
    enables protein binding PubMed 
    enables protein-containing complex binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in extracellular exosome  
    located_in lipid droplet  
    is_active_in nucleus  

    General protein information

    Preferred Names
    heat shock 70 kDa protein 4
    Names
    heat shock 70-related protein APG-2
    heat shock protein, 110 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008300.3NP_032326.3  heat shock 70 kDa protein 4

      See identical proteins and their annotated locations for NP_032326.3

      Status: VALIDATED

      Source sequence(s)
      AA203833, AI316935, AL596382, AW545353, CA316420, CF741432, CN458707
      Consensus CDS
      CCDS24674.1
      UniProtKB/Swiss-Prot
      Q61316
      UniProtKB/TrEMBL
      Q3U2G2
      Related
      ENSMUSP00000020630.8, ENSMUST00000020630.8
      Conserved Domains (2) summary
      cd11737
      Location:2384
      HSPA4_NBD; Nucleotide-binding domain of HSPA4
      pfam00012
      Location:3609
      HSP70; Hsp70 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      53150641..53191306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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