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    FEN2 Fen2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850394, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FEN2
    Official Full Name
    Fen2p
    Primary source
    SGD:S000000623
    Locus tag
    YCR028C
    See related
    AllianceGenome:SGD:S000000623; FungiDB:YCR028C; VEuPathDB:YCR028C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pantothenate transmembrane transporter activity. Involved in endocytosis and pantothenate transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25; gout; porokeratosis; and sialuria. Orthologous to several human genes including SLC17A1 (solute carrier family 17 member 1); SLC17A2 (solute carrier family 17 member 2); and SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FEN2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (170886..172424, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative GTPase RHB1 Neighboring gene tRNA-Gln Neighboring gene Rim1p Neighboring gene Syp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast. Marcireau C, et al. Yeast, 1996 May. PMID 8771708
    2. The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter. Stolz J, et al. J Biol Chem, 1999 Jun 25. PMID 10373490
    3. Nucleotide sequence of 9.2 kb left of CRY1 on yeast chromosome III from strain AB972: evidence for a Ty insertion and functional analysis of open reading frame YCR28. Agostoni Carbone ML, et al. Yeast, 1992 Sep. PMID 1332309
    4. Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum. Augagneur Y, et al. J Biol Chem, 2013 Jul 12. PMID 23729665, Free PMC Article
    5. Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant. Stolz J, et al. J Biol Chem, 1999 Jun 25. PMID 10373489

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables pantothenate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantothenate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pantothenate import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pantothenate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fen2p
    NP_009957.1
    • Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      170886..172424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178743.1 → NP_009957.1  TPA: Fen2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR38, P25621
      UniProtKB/TrEMBL
      A6ZTK9, B3LU99, B5VEX5, C7GQ16, G2WA46, N1PAQ3
      Conserved Domains (1) summary
      cd17327
      Location:32 → 450
      MFS_FEN2_like; Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25621.1

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