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    Pfn2 profilin 2 [ Mus musculus (house mouse) ]

    Gene ID: 18645, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pfn2provided by MGI
    Official Full Name
    profilin 2provided by MGI
    Primary source
    MGI:MGI:97550
    See related
    Ensembl:ENSMUSG00000027805 AllianceGenome:MGI:97550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pfn
    Summary
    Predicted to enable actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including negative regulation of ruffle assembly; positive regulation of stress fiber assembly; and synapse organization. Acts upstream of or within positive regulation of actin filament polymerization and regulation of synaptic vesicle exocytosis. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 159.8), whole brain E14.5 (RPKM 144.6) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Pfn2 in Genome Data Viewer
    Location:
    3 D; 3 28.15 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (57749316..57755178, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (57841895..57847757, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 13 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07740 Neighboring gene predicted gene, 32753 Neighboring gene predicted gene, 40055 Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07741 Neighboring gene STARR-seq mESC enhancer starr_07742 Neighboring gene predicted gene, 40056 Neighboring gene predicted gene 5537

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity  
    enables actin binding  
    enables actin binding  
    enables actin monomer binding  
    enables actin monomer binding  
    enables phosphatidylinositol-4,5-bisphosphate binding  
    enables phosphatidylinositol-4,5-bisphosphate binding  
    enables protein binding PubMed 
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in modification of postsynaptic actin cytoskeleton PubMed 
    involved_in modification of postsynaptic actin cytoskeleton PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in negative regulation of actin filament polymerization  
    involved_in negative regulation of actin filament polymerization  
    involved_in negative regulation of epithelial cell migration PubMed 
    involved_in negative regulation of epithelial cell migration  
    involved_in negative regulation of ruffle assembly PubMed 
    involved_in negative regulation of ruffle assembly  
    involved_in positive regulation of ATP-dependent activity  
    involved_in positive regulation of actin filament bundle assembly  
    involved_in positive regulation of actin filament bundle assembly  
    acts_upstream_of_or_within positive regulation of actin filament polymerization PubMed 
    involved_in positive regulation of actin filament polymerization  
    involved_in positive regulation of peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of stress fiber assembly PubMed 
    involved_in positive regulation of stress fiber assembly  
    involved_in presynaptic actin cytoskeleton organization PubMed 
    involved_in presynaptic actin cytoskeleton organization PubMed 
    involved_in presynaptic actin cytoskeleton organization PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of actin filament polymerization  
    involved_in regulation of actin filament polymerization  
    acts_upstream_of_or_within regulation of synaptic vesicle exocytosis PubMed 
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in cytoplasm  
    located_in cytoskeleton  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in postsynapse PubMed 
    is_active_in presynapse PubMed 

    General protein information

    Preferred Names
    profilin-2
    Names
    profilin II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019410.3NP_062283.1  profilin-2

      See identical proteins and their annotated locations for NP_062283.1

      Status: VALIDATED

      Source sequence(s)
      AC165888, AK132651
      Consensus CDS
      CCDS17364.1
      UniProtKB/Swiss-Prot
      Q3TPT7, Q3V171, Q9ES48, Q9ES49, Q9ES50, Q9JJV2
      Related
      ENSMUSP00000068890.9, ENSMUST00000066882.10
      Conserved Domains (1) summary
      smart00392
      Location:2140
      PROF; Profilin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      57749316..57755178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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