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    MX1 MX dynamin like GTPase 1 [ Homo sapiens (human) ]

    Gene ID: 4599, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MX1provided by HGNC
    Official Full Name
    MX dynamin like GTPase 1provided by HGNC
    Primary source
    HGNC:HGNC:7532
    See related
    Ensembl:ENSG00000157601 MIM:147150; AllianceGenome:HGNC:7532
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MX; MxA; IFI78; IFI-78K; lncMX1-215
    Summary
    This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Ubiquitous expression in spleen (RPKM 25.6), salivary gland (RPKM 13.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MX1 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (41420558..41459214)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (39807998..39847898)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (42792485..42831141)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18470 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:42731293-42732096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42739613-42740114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42740714-42741402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42741403-42742089 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 21:42745414 Neighboring gene melanoma risk locus-associated MPRA allelic enhancers 21:42746568 and 21:42746578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42750497-42750998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42750999-42751498 Neighboring gene MX dynamin like GTPase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18479 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:42824122-42825321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42830117-42830618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42851654-42852154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42852155-42852655 Neighboring gene transmembrane serine protease 2 Neighboring gene transmembrane protease serine 2 breakpoint cluster recombination region Neighboring gene TMPRSS2 promoter region Neighboring gene TMPRSS2 repressive element NBS1 Neighboring gene TMPRSS2 repressive element NBS2 Neighboring gene TMPRSS2 repressive element NBS4 Neighboring gene TMPRSS2 androgen receptor-responsive -13 kb enhancer Neighboring gene TMPRSS2 -17 kb enhancer Neighboring gene TMPRSS2 E3 enhancer Neighboring gene uncharacterized LOC124905021

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single nucleotide polymorphisms and functional analysis of MxA promoter region in multiple sclerosis. Furuyama H, et al. J Neurol Sci, 2006 Nov 15. PMID 16843495
    2. Use of a standardized MxA protein measurement-based assay for validation of assays for the assessment of neutralizing antibodies against interferon-β. Wadhwa M, et al. J Interferon Cytokine Res, 2013 Nov. PMID 23848523, Free PMC Article
    3. Immunological changes and increased expression of myxovirus resistance protein a in thyroid tissue of patients with recent onset and untreated Graves' disease. Hammerstad SS, et al. Thyroid, 2014 Mar. PMID 24032645
    4. West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein. Hoenen A, et al. J Gen Virol, 2007 Nov. PMID 17947524
    5. Interferon-induced Mx proteins in antiviral host defense. Haller O, et al. Biochimie, 2007 Jun-Jul. PMID 17570575

    See all (228) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells.
      Title: Oral Antiviral Defense: Saliva- and Beverage-like Hypotonicity Dynamically Regulate Formation of Membraneless Biomolecular Condensates of Antiviral Human MxA in Oral Epithelial Cells.
    2. Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis.
      Title: Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis.
    3. Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.
      Title: Polymorphisms of IFN signaling genes and FOXP4 influence the severity of COVID-19.
    4. Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis.
      Title: Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis.
    5. Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity.
      Title: Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity.
    6. Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
      Title: Genome-wide DNA methylation analysis implicates enrichment of interferon pathway in African American patients with Systemic Lupus Erythematosus and European Americans with lupus nephritis.
    7. Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication.
      Title: Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication.
    8. An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses.
      Title: An evolutionarily conserved N-terminal leucine is essential for MX1 GTPase antiviral activity against different families of RNA viruses.
    9. Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.
      Title: Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.
    10. Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.
      Title: Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.
    Submit: New GeneRIF Correction See all GeneRIFs (157)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 replication is restricted by wild type MX1 (MxA); restriction is dependent on amino acids M527 in MX1 as assayed in U87-MG CD4+ CXCR4+ cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of MX dynamin-like GTPase 1 (MX1; MxA; IFI78) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including MX1, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of MX1 in human monocyte-derived dendritic cells PubMed
    vpr HIV-1 Vpr upregulates the gene expression of MX1 in human monocyte-derived macrophages PubMed
    vpr HIV-1 Vpr downregulates MX1 expression in human glial cells PubMed
    Vpu vpu The expression of MX1 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in interleukin-27-mediated signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to type I interferon TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced GTP-binding protein Mx1
    Names
    interferon-induced protein p78
    interferon-inducible protein p78
    interferon-regulated resistance GTP-binding protein MxA
    myxoma resistance protein 1
    myxovirus (influenza virus) resistance 1, interferon-inducible protein p78

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027788.2 RefSeqGene

      Range
      10647..43620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144925.2 → NP_001138397.1  interferon-induced GTP-binding protein Mx1 isoform a

      See identical proteins and their annotated locations for NP_001138397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as T0) represents the longest transcript and encodes isoform a. Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      AK096355, BC032602, DA726666, EB388095, M33882
      Consensus CDS
      CCDS13673.1
      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000381601.2, ENST00000398600.6
      Conserved Domains (3) summary
      smart00302
      Location:571 → 660
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:260 → 546
      Dynamin_M; Dynamin central region

    2. NM_001178046.3 → NP_001171517.1  interferon-induced GTP-binding protein Mx1 isoform a

      See identical proteins and their annotated locations for NP_001171517.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks five exons and contains an alternate terminal exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      AK315465, BC032602, EB388095, M33882
      Consensus CDS
      CCDS13673.1
      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000410523.2, ENST00000455164.6
      Conserved Domains (3) summary
      smart00302
      Location:571 → 660
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:260 → 546
      Dynamin_M; Dynamin central region

    3. NM_001282920.1 → NP_001269849.1  interferon-induced GTP-binding protein Mx1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks three exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b, also known as varMxA) is shorter and has a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID: 20603636.
      Source sequence(s)
      BC032602, EB388095, M33882
      Consensus CDS
      CCDS74796.1
      UniProtKB/TrEMBL
      A0A7P0Z4E0
      Related
      ENSP00000478441.1, ENST00000619682.1
      Conserved Domains (3) summary
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:130 → 357
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:261 → 424
      Dynamin_M; Dynamin central region

    4. NM_002462.5 → NP_002453.2  interferon-induced GTP-binding protein Mx1 isoform a

      See identical proteins and their annotated locations for NP_002453.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as T1) lacks three exons and contains an alternate terminal exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      BC032602, EB388095, M33882
      Consensus CDS
      CCDS13673.1
      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000381599.3, ENST00000398598.8
      Conserved Domains (3) summary
      smart00302
      Location:571 → 660
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:260 → 546
      Dynamin_M; Dynamin central region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      41420558..41459214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028349.3 → XP_016883838.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Conserved Domains (3) summary
      smart00302
      Location:571 → 660
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:260 → 546
      Dynamin_M; Dynamin central region

    2. XM_047440771.1 → XP_047296727.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1, H9KVC7

    3. XM_047440769.1 → XP_047296725.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000505657.1, ENST00000681191.1

    4. XM_011529568.3 → XP_011527870.1  interferon-induced GTP-binding protein Mx1 isoform X1

      See identical proteins and their annotated locations for XP_011527870.1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Conserved Domains (3) summary
      smart00302
      Location:571 → 660
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:260 → 546
      Dynamin_M; Dynamin central region

    5. XM_047440765.1 → XP_047296721.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000506183.1, ENST00000680347.1

    6. XM_047440766.1 → XP_047296722.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000506062.1, ENST00000681415.1

    7. XM_047440767.1 → XP_047296723.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000506395.1, ENST00000680182.1

    8. XM_047440768.1 → XP_047296724.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000506220.1, ENST00000681039.1

    9. XM_047440770.1 → XP_047296726.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000506712.1, ENST00000681671.1

    10. XM_005260978.5 → XP_005261035.1  interferon-induced GTP-binding protein Mx1 isoform X1

      See identical proteins and their annotated locations for XP_005261035.1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000506512.1, ENST00000680776.1
      Conserved Domains (3) summary
      smart00302
      Location:571 → 660
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:260 → 546
      Dynamin_M; Dynamin central region

    11. XM_017028352.2 → XP_016883841.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1, H9KVC7
      Related
      ENSP00000505269.1, ENST00000679408.1
      Conserved Domains (4) summary
      smart00302
      Location:518 → 607
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:130 → 357
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:261 → 493
      Dynamin_M; Dynamin central region

    12. XM_005260980.3 → XP_005261037.1  interferon-induced GTP-binding protein Mx1 isoform X1

      See identical proteins and their annotated locations for XP_005261037.1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000506348.1, ENST00000681266.1
      Conserved Domains (3) summary
      smart00302
      Location:571 → 660
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:260 → 546
      Dynamin_M; Dynamin central region

    13. XM_047440772.1 → XP_047296728.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1, H9KVC7

    14. XM_017028351.3 → XP_016883840.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1, H9KVC7
      Related
      ENSP00000400923.2, ENST00000424365.6
      Conserved Domains (4) summary
      smart00302
      Location:518 → 607
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:130 → 357
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:261 → 493
      Dynamin_M; Dynamin central region

    15. XM_005260982.3 → XP_005261039.1  interferon-induced GTP-binding protein Mx1 isoform X1

      See identical proteins and their annotated locations for XP_005261039.1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000402215.2, ENST00000417963.6
      Conserved Domains (3) summary
      smart00302
      Location:571 → 660
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:260 → 546
      Dynamin_M; Dynamin central region

    16. XM_047440774.1 → XP_047296730.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1, H9KVC7

    17. XM_005260981.3 → XP_005261038.1  interferon-induced GTP-binding protein Mx1 isoform X1

      See identical proteins and their annotated locations for XP_005261038.1

      UniProtKB/Swiss-Prot
      B2RDA5, B3KU10, C9IYV7, C9J8D6, C9JN19, C9JN88, C9JUL1, C9JZS6, D3DSI8, P20591, Q86YP5, Q96CI3
      UniProtKB/TrEMBL
      F8W8T1
      Related
      ENSP00000505051.1, ENST00000681849.1
      Conserved Domains (3) summary
      smart00302
      Location:571 → 660
      GED; Dynamin GTPase effector domain
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:260 → 546
      Dynamin_M; Dynamin central region

    18. XM_047440773.1 → XP_047296729.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1, H9KVC7

    19. XM_047440776.1 → XP_047296732.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0

    20. XM_047440777.1 → XP_047296733.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0

    21. XM_047440775.1 → XP_047296731.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0

    22. XM_047440778.1 → XP_047296734.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0

    23. XM_011529570.4 → XP_011527872.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0
      Conserved Domains (3) summary
      cd08771
      Location:68 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:130 → 357
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:261 → 425
      Dynamin_M; Dynamin central region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      39807998..39847898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324489.1 → XP_054180464.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    2. XM_054324474.1 → XP_054180449.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    3. XM_054324494.1 → XP_054180469.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1

    4. XM_054324488.1 → XP_054180463.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    5. XM_054324490.1 → XP_054180465.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    6. XM_054324487.1 → XP_054180462.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    7. XM_054324493.1 → XP_054180468.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1

    8. XM_054324483.1 → XP_054180458.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    9. XM_054324492.1 → XP_054180467.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1

    10. XM_054324470.1 → XP_054180445.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    11. XM_054324481.1 → XP_054180456.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    12. XM_054324478.1 → XP_054180453.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    13. XM_054324473.1 → XP_054180448.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    14. XM_054324475.1 → XP_054180450.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    15. XM_054324484.1 → XP_054180459.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    16. XM_054324476.1 → XP_054180451.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    17. XM_054324471.1 → XP_054180446.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    18. XM_054324482.1 → XP_054180457.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    19. XM_054324495.1 → XP_054180470.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1

    20. XM_054324500.1 → XP_054180475.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0

    21. XM_054324480.1 → XP_054180455.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    22. XM_054324496.1 → XP_054180471.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1

    23. XM_054324491.1 → XP_054180466.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1

    24. XM_054324486.1 → XP_054180461.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    25. XM_054324498.1 → XP_054180473.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1

    26. XM_054324472.1 → XP_054180447.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    27. XM_054324497.1 → XP_054180472.1  interferon-induced GTP-binding protein Mx1 isoform X2

      UniProtKB/TrEMBL
      F8W8T1

    28. XM_054324501.1 → XP_054180476.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0

    29. XM_054324499.1 → XP_054180474.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0

    30. XM_054324503.1 → XP_054180478.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0

    31. XM_054324502.1 → XP_054180477.1  interferon-induced GTP-binding protein Mx1 isoform X3

      UniProtKB/TrEMBL
      A0A7P0Z4E0

    32. XM_054324477.1 → XP_054180452.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    33. XM_054324479.1 → XP_054180454.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1

    34. XM_054324485.1 → XP_054180460.1  interferon-induced GTP-binding protein Mx1 isoform X1

      UniProtKB/TrEMBL
      F8W8T1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20591.4 GenPept UniProtKB/Swiss-Prot:P20591

    Gene LinkOut

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