HIS1 ATP phosphoribosyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HIS1
Official Full Name: ATP phosphoribosyltransferase
Primary source: SGD:S000000857
Locus tag: YER055C
See related: AllianceGenome:SGD:S000000857; FungiDB:YER055C; VEuPathDB:YER055C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATP phosphoribosyltransferase activity. Involved in L-histidine biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HIS1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (264892..265785, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ATP phosphoribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-histidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-histidine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-histidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP phosphoribosyltransferase

NP_010975.3

EC 2.4.2.17

ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

264892..265785 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178946.3 → NP_010975.3 TPA: ATP phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010975.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLV8, P00498

UniProtKB/TrEMBL

A6ZR07, C7GX46, C8Z760, G2WCU1, N1P551

Conserved Domains (1) summary

COG0040
Location:9 → 297

HisG; ATP phosphoribosyltransferase [Amino acid transport and metabolism]