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    SUMO4 small ubiquitin like modifier 4 [ Homo sapiens (human) ]

    Gene ID: 387082, updated on 10-Dec-2024

    Summary

    Official Symbol
    SUMO4provided by HGNC
    Official Full Name
    small ubiquitin like modifier 4provided by HGNC
    Primary source
    HGNC:HGNC:21181
    See related
    Ensembl:ENSG00000177688 MIM:608829; AllianceGenome:HGNC:21181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IDDM5; SMT3H4; SUMO-4; dJ281H8.4
    Summary
    This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See SUMO4 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149400262..149401278)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150600139..150601155)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149721398..149722414)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TGF-beta activated kinase 1 (MAP3K7) binding protein 2 Neighboring gene RNA, 7SL, cytoplasmic 234, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25253 Neighboring gene fatty acid binding protein 12 pseudogene 1 Neighboring gene MPRA-validated peak6211 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25254 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:149699707-149700906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149746425-149746924 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:149753111-149753397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149761776-149762690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149772303-149772854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149772855-149773406 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25256 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:149794343-149794528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149802875-149803730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149805477-149806341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25260 Neighboring gene coiled-coil domain containing 59 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein tag activity  
    enables ubiquitin-like protein ligase binding  
    Component Evidence Code Pubs
    part_of SUMO ligase complex PubMed 
    is_active_in nucleus  

    General protein information

    Preferred Names
    small ubiquitin-related modifier 4
    Names
    SMT3 suppressor of mif two 3 homolog 2
    SMT3 suppressor of mif two 3 homolog 4
    insulin-dependent diabetes mellitus 5
    small ubiquitin-like modifier 4 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012301.1 RefSeqGene

      Range
      4904..5920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001002255.2NP_001002255.1  small ubiquitin-related modifier 4

      See identical proteins and their annotated locations for NP_001002255.1

      Status: REVIEWED

      Source sequence(s)
      AL031133, AY340238
      Consensus CDS
      CCDS34549.1
      UniProtKB/Swiss-Prot
      A1L3W5, Q6EEV6
      Related
      ENSP00000318635.4, ENST00000326669.6
      Conserved Domains (1) summary
      cd01763
      Location:893
      Sumo; Small ubiquitin-related modifier (SUMO)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      149400262..149401278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      150600139..150601155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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