KLK10 kallikrein related peptidase 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLK10provided by HGNC
Official Full Name: kallikrein related peptidase 10provided by HGNC
Primary source: HGNC:HGNC:6358
See related: Ensembl:ENSG00000129451 MIM:602673; AllianceGenome:HGNC:6358
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NES1; PRSSL1
Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Expression: Biased expression in esophagus (RPKM 28.7), skin (RPKM 8.9) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.41

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (51012739..51020097, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (54101211..54108579, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (51515995..51523353, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis.
Title: MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis.
KLK10 derived from tumor endothelial cells accelerates colon cancer cell proliferation and hematogenous liver metastasis formation.
Title: KLK10 derived from tumor endothelial cells accelerates colon cancer cell proliferation and hematogenous liver metastasis formation.
KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
Title: KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
Kallikrein-related peptidase 10 predicts prognosis and mediates tumor immunomodulation in colorectal cancer.
Title: Kallikrein-related peptidase 10 predicts prognosis and mediates tumor immunomodulation in colorectal cancer.
Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia.
Title: Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia.
miR-194-3p represses the docetaxel resistance in colon cancer by targeting KLK10.
Title: miR-194-3p represses the docetaxel resistance in colon cancer by targeting KLK10.
MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10.
Title: MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10.
The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility.
Title: The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility.
Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway.
Title: Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway.
The data suggest that via inhibition of BCL-2 expression, overexpressed NES1 might enhance the effect of radiation therapy of (131)I uptake in hNIS overexpressed PC3 cells.
Title: NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

PMC156606P1 (e-PCR)
- UniSTS:271408

PMC156606P2 (e-PCR)
- UniSTS:271409

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

RH48452 (e-PCR)
- UniSTS:29811

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-10

Names: breast normal epithelial cell associated serine protease; kallikrein 10 protein 1; kallikrein 10 protein 12; kallikrein 10 protein 13; kallikrein 10 protein 2; kallikrein 10 protein 3; kallikrein 10 protein 4; kallikrein 10 protein 5; kallikrein 10 protein 7; kallikrein 10 protein 8; kallikrein 10 protein 9; normal epithelial cell-specific 1; protease serine-like 1

NP_001070968.1

EC 3.4.21.35

NP_002767.2

EC 3.4.21.35

NP_665895.1

EC 3.4.21.35

XP_005259118.1

EC 3.4.21.35

XP_005259119.1

EC 3.4.21.35

XP_006723350.1

EC 3.4.21.35

XP_006723352.1

EC 3.4.21.35

XP_016882482.1

EC 3.4.21.35

XP_047295058.1

EC 3.4.21.35

XP_054177453.1

EC 3.4.21.35

XP_054177454.1

EC 3.4.21.35

XP_054177455.1

EC 3.4.21.35

XP_054177456.1

EC 3.4.21.35

XP_054177457.1

EC 3.4.21.35

XP_054177458.1

EC 3.4.21.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077500.2 → NP_001070968.1 kallikrein-10 preproprotein

See identical proteins and their annotated locations for NP_001070968.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.

Source sequence(s)

AC011473, AY561635, BM830577, BU685208

Consensus CDS

CCDS12817.1

UniProtKB/Swiss-Prot

A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

UniProtKB/TrEMBL

W8GRM7, W8GWD1

Related

ENSP00000375681.1, ENST00000391805.5

Conserved Domains (2) summary

smart00020
Location:49 → 269

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:49 → 272

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_002776.5 → NP_002767.2 kallikrein-10 preproprotein

See identical proteins and their annotated locations for NP_002767.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All transcript variants encode the same protein.

Source sequence(s)

AC011473, AY561635, BC002710, BU685208

Consensus CDS

CCDS12817.1

UniProtKB/Swiss-Prot

A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

UniProtKB/TrEMBL

W8GRM7, W8GWD1

Related

ENSP00000311746.2, ENST00000309958.7

Conserved Domains (2) summary

smart00020
Location:49 → 269

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:49 → 272

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_145888.3 → NP_665895.1 kallikrein-10 preproprotein

See identical proteins and their annotated locations for NP_665895.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All transcript variants encode the same protein.

Source sequence(s)

AC011473, AF024605, AY561635, BU685208

Consensus CDS

CCDS12817.1

UniProtKB/Swiss-Prot

A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

UniProtKB/TrEMBL

W8GRM7, W8GWD1

Related

ENSP00000351640.2, ENST00000358789.8

Conserved Domains (2) summary

smart00020
Location:49 → 269

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:49 → 272

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

51012739..51020097 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047439102.1 → XP_047295058.1 kallikrein-10 isoform X1

UniProtKB/Swiss-Prot

A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

UniProtKB/TrEMBL

W8GRM7, W8GWD1
XM_006723289.4 → XP_006723352.1 kallikrein-10 isoform X1

See identical proteins and their annotated locations for XP_006723352.1

UniProtKB/Swiss-Prot

A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

UniProtKB/TrEMBL

W8GRM7, W8GWD1

Conserved Domains (2) summary

smart00020
Location:49 → 269

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:49 → 272

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_005259061.4 → XP_005259118.1 kallikrein-10 isoform X1

See identical proteins and their annotated locations for XP_005259118.1

UniProtKB/Swiss-Prot

A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

UniProtKB/TrEMBL

W8GRM7, W8GWD1

Conserved Domains (2) summary

smart00020
Location:49 → 269

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:49 → 272

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006723287.5 → XP_006723350.1 kallikrein-10 isoform X1

See identical proteins and their annotated locations for XP_006723350.1

UniProtKB/Swiss-Prot

A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

UniProtKB/TrEMBL

W8GRM7, W8GWD1

Conserved Domains (2) summary

smart00020
Location:49 → 269

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:49 → 272

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_005259062.4 → XP_005259119.1 kallikrein-10 isoform X1

See identical proteins and their annotated locations for XP_005259119.1

UniProtKB/Swiss-Prot

A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

UniProtKB/TrEMBL

W8GRM7, W8GWD1

Conserved Domains (2) summary

smart00020
Location:49 → 269

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:49 → 272

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_017026993.3 → XP_016882482.1 kallikrein-10 isoform X1

UniProtKB/Swiss-Prot

A6NC12, O43240, Q53YL3, Q99920, Q9GZW9

UniProtKB/TrEMBL

W8GRM7, W8GWD1

Conserved Domains (2) summary

smart00020
Location:49 → 269

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:49 → 272

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...