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    RRAGD Ras related GTP binding D [ Homo sapiens (human) ]

    Gene ID: 58528, updated on 10-Dec-2024

    Summary

    Official Symbol
    RRAGDprovided by HGNC
    Official Full Name
    Ras related GTP binding Dprovided by HGNC
    Primary source
    HGNC:HGNC:19903
    See related
    Ensembl:ENSG00000025039 MIM:608268; AllianceGenome:HGNC:19903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAGD; HOMG7; bA11D8.2.1
    Summary
    RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]
    Expression
    Broad expression in thyroid (RPKM 16.9), heart (RPKM 13.1) and 20 other tissues See more
    Orthologs
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    Genomic context

    See RRAGD in Genome Data Viewer
    Location:
    6q15
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (89364616..89412273, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (90573972..90621638, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90074335..90121992, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit rho2 Neighboring gene tubulin beta 3 class III pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:90061747-90062696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24823 Neighboring gene ubiquitin conjugating enzyme E2 J1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24824 Neighboring gene Sharpr-MPRA regulatory region 13381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90084816-90085316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90085317-90085817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17393 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17394 Neighboring gene uncharacterized LOC124901360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17395 Neighboring gene NACA pseudogene 7 Neighboring gene ankyrin repeat domain 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ44176, DKFZp761H171

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding PubMed 
    enables GDP binding PubMed 
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables GTPase binding PubMed 
    enables membrane scission GTPase motor activity  
    enables molecular adaptor activity PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine PubMed 
    involved_in cellular response to amino acid stimulus  
    involved_in cellular response to leucine starvation PubMed 
    involved_in cellular response to starvation  
    involved_in negative regulation of autophagy  
    involved_in positive regulation of TOR signaling PubMed 
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of TORC1 signaling PubMed 
    involved_in protein localization  
    Component Evidence Code Pubs
    part_of Gtr1-Gtr2 GTPase complex  
    located_in centrosome  
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in lysosomal membrane  
    is_active_in lysosome  
    located_in lysosome PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    ras-related GTP-binding protein D
    Names
    Rag D protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021244.5 → NP_067067.1  ras-related GTP-binding protein D

      See identical proteins and their annotated locations for NP_067067.1

      Status: VALIDATED

      Source sequence(s)
      AK289799, AL138717, AL523999, DB472739
      Consensus CDS
      CCDS5022.1
      UniProtKB/Swiss-Prot
      A8K184, Q7L8F9, Q9NPG0, Q9NQL2
      Related
      ENSP00000358423.4, ENST00000369415.9
      Conserved Domains (1) summary
      cd11385
      Location:64 → 238
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      89364616..89412273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      90573972..90621638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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