THI5 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: THI5
Official Full Name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
Primary source: SGD:S000001836
Locus tag: YFL058W
See related: AllianceGenome:SGD:S000001836; FungiDB:YFL058W; VEuPathDB:YFL058W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable metal ion binding activity and transferase activity. Involved in thiamine biosynthetic process. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See THI5 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (12929..13951)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

structure-function study of the HMP-P synthase from yeast, THI5p
Title: The last piece in the vitamin B1 biosynthesis puzzle: structural and functional insight into yeast 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in thiamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thiamine diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase

NP_116597.1

Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

12929..13951

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179909.1 → NP_116597.1 TPA: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116597.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTH2, P43534

UniProtKB/TrEMBL

A6ZQB8, C8ZGJ3, G2WHG4

Conserved Domains (1) summary

cd13650
Location:5 → 255

PBP2_THI5; Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily