RET2 coatomer subunit delta [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RET2
Official Full Name: coatomer subunit delta
Primary source: SGD:S000001947
Locus tag: YFR051C
See related: AllianceGenome:SGD:S000001947; FungiDB:YFR051C; VEuPathDB:YFR051C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Acts upstream of or within Golgi distribution to daughter cells. Part of COPI vesicle coat. Orthologous to human ARCN1 (archain 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RET2 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (250163..251803, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

delta-COP subunits bind Wxn(1-6)[WF] motifs within unstructured regions of proteins that influence the lifecycle of COPI-coated vesicles
Title: Structural basis for the binding of tryptophan-based motifs by δ-COP.
component of a Myo2 receptor complex that functions during the Golgi inheritance into the growing bud
Title: Ypt11 functions in bud-directed transport of the Golgi by linking Myo2 to the coatomer subunit Ret2.
Two highly conserved stretches--in the beta- and delta-COPI subunits--are required to maintain Pmp2GFP reporters exposing R-based signals in the endoplasmic reticulum.
Title: Novel cargo-binding site in the beta and delta subunits of coatomer.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi distribution to daughter cells	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Golgi inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPI vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPI vesicle coat	IDA Inferred from Direct Assay more info	PubMed
part_of COPI vesicle coat	IEA Inferred from Electronic Annotation more info
part_of COPI vesicle coat	IMP Inferred from Mutant Phenotype more info	PubMed
located_in COPI-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of membrane coat	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coatomer subunit delta

NP_116709.3

Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

250163..251803 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180016.3 → NP_116709.3 TPA: coatomer subunit delta [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116709.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTT4, P43621

UniProtKB/TrEMBL

A7A291, B3LUR2, B5VI76, C7GYF4, C8Z7Y6, G2WDJ2, N1P4G2

Conserved Domains (2) summary

cd09254
Location:289 → 543

AP_delta-COPI_MHD; Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit

cd14830
Location:4 → 135

Delta_COP_N; delta subunit of the F-COPI complex, N-terminal domain