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    ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [ Homo sapiens (human) ]

    Gene ID: 8853, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ASAP2provided by HGNC
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 2provided by HGNC
    Primary source
    HGNC:HGNC:2721
    See related
    Ensembl:ENSG00000151693 MIM:603817; AllianceGenome:HGNC:2721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAP; PAG3; AMAP2; DDEF2; SHAG1; CENTB3; Pap-alpha
    Summary
    This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
    Expression
    Broad expression in testis (RPKM 24.6), kidney (RPKM 11.9) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ASAP2 in Genome Data Viewer
    Location:
    2p25.1; 2p24
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (9206812..9405678)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (9230598..9430981)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (9346941..9545807)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373416 Neighboring gene uncharacterized LOC105373415 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:9269636-9269796 Neighboring gene uncharacterized LOC105373417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9279832-9280332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9282151-9283048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9289685-9290604 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:9319676-9320875 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:9346090-9347022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:9347023-9347953 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:9357948-9358822 Neighboring gene Sharpr-MPRA regulatory region 15524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9371198-9371754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9371755-9372309 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:9374524-9375723 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:9427423-9428622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9439781-9440280 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 7 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:9495983-9497182 Neighboring gene Sharpr-MPRA regulatory region 10317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9513595-9514143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9514144-9514692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9518857-9519441 Neighboring gene uncharacterized LOC124907730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9532979-9533616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9533617-9534254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9540673-9541236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9562108-9562966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15278 Neighboring gene integrin subunit beta 1 binding protein 1 Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9614491-9615258 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:9615739-9616299 Neighboring gene isoamyl acetate hydrolyzing esterase 1 (putative) Neighboring gene ADAM metallopeptidase domain 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages. Seuter S, et al. J Steroid Biochem Mol Biol, 2014 Oct. PMID 23999061
    2. The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer. Fujii A, et al. Cancer Sci, 2021 Apr. PMID 33605496, Free PMC Article
    3. A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function. Hashimoto S, et al. J Biol Chem, 2004 Sep 3. PMID 15231847
    4. PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages. Uchida H, et al. J Exp Med, 2001 Apr 16. PMID 11304556, Free PMC Article
    5. Regulation of Bin1 SH3 domain binding by phosphoinositides. Kojima C, et al. EMBO J, 2004 Nov 10. PMID 15483625, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer.
      Title: The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Replication of top markers of a genome-wide association study in multiple sclerosis in Spain.
    3. regulates multiple cytokine and growth factor-activated signaling pathways by acting as a recruitment factor for adapter proteins
      Title: A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42910, KIAA0400

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
    Names
    PYK2 C terminus-associated protein
    centaurin, beta 3
    development and differentiation-enhancing factor 2
    paxillin-associated protein with ARF GAP activity 3
    pyk2 C-terminus-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135191.2 → NP_001128663.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform b

      See identical proteins and their annotated locations for NP_001128663.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform b) is lacking a 45-aa portion of the proline-rich region, compared to isoform a.
      Source sequence(s)
      AA918883, AB007860, AC079782, BC063308
      Consensus CDS
      CCDS46224.1
      UniProtKB/Swiss-Prot
      O43150
      Related
      ENSP00000316404.4, ENST00000315273.4
      Conserved Domains (6) summary
      cd07642
      Location:34 → 248
      BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
      cd11966
      Location:903 → 958
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd13251
      Location:297 → 403
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:586 → 618
      ANK; ANK repeat [structural motif]
      cd08849
      Location:419 → 541
      ArfGap_ASAP2; ArfGAP domain of ASAP2 (ArfGAP2 with SH3 domain, ANK repeat and PH domain-containing protein 2)
      pfam12796
      Location:589 → 673
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_003887.3 → NP_003878.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform a

      See identical proteins and their annotated locations for NP_003878.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AA918883, AB007860, AC079782
      Consensus CDS
      CCDS1661.1
      UniProtKB/Swiss-Prot
      D6W4Y8, O43150
      Related
      ENSP00000281419.3, ENST00000281419.8
      Conserved Domains (8) summary
      cd07642
      Location:34 → 248
      BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
      cd11966
      Location:948 → 1003
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:579 → 673
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:297 → 403
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:306 → 393
      PH; PH domain
      pfam01412
      Location:421 → 538
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:607 → 661
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:586 → 618
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      9206812..9405678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510403.4 → XP_011508705.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1

      Conserved Domains (8) summary
      cd11966
      Location:962 → 1017
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:593 → 687
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:311 → 417
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:320 → 407
      PH; PH domain
      pfam01412
      Location:435 → 552
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:621 → 675
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:600 → 632
      ANK; ANK repeat [structural motif]
      cl12013
      Location:34 → 259
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_011510407.3 → XP_011508709.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X8

      Conserved Domains (8) summary
      cd11966
      Location:917 → 972
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:593 → 687
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:311 → 417
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:320 → 407
      PH; PH domain
      pfam01412
      Location:435 → 552
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:621 → 675
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:600 → 632
      ANK; ANK repeat [structural motif]
      cl12013
      Location:34 → 259
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_011510404.3 → XP_011508706.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2

      Conserved Domains (8) summary
      cd11966
      Location:959 → 1014
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:590 → 684
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:308 → 414
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:317 → 404
      PH; PH domain
      pfam01412
      Location:432 → 549
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:618 → 672
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:597 → 629
      ANK; ANK repeat [structural motif]
      cl12013
      Location:34 → 259
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_047446201.1 → XP_047302157.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X9

    5. XM_011510405.4 → XP_011508707.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X4

      Conserved Domains (8) summary
      cd11966
      Location:937 → 992
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:568 → 662
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:286 → 392
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:295 → 382
      PH; PH domain
      pfam01412
      Location:410 → 527
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:596 → 650
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:575 → 607
      ANK; ANK repeat [structural motif]
      cl12013
      Location:34 → 234
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_047446199.1 → XP_047302155.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X5

    7. XM_047446208.1 → XP_047302164.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X15

    8. XM_011510406.3 → XP_011508708.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X7

      Conserved Domains (8) summary
      cd11966
      Location:920 → 975
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:551 → 645
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:269 → 375
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:278 → 365
      PH; PH domain
      pfam01412
      Location:393 → 510
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:579 → 633
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:558 → 590
      ANK; ANK repeat [structural motif]
      cl12013
      Location:11 → 217
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_006711898.2 → XP_006711961.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3

      Conserved Domains (8) summary
      cd07642
      Location:34 → 248
      BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
      cd11966
      Location:951 → 1006
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:582 → 676
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:300 → 406
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:309 → 396
      PH; PH domain
      pfam01412
      Location:424 → 541
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:610 → 664
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:589 → 621
      ANK; ANK repeat [structural motif]

    10. XM_006711902.2 → XP_006711965.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X12

      Conserved Domains (8) summary
      cd07642
      Location:34 → 248
      BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
      cd11966
      Location:906 → 961
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:582 → 676
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:300 → 406
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:309 → 396
      PH; PH domain
      pfam01412
      Location:424 → 541
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:610 → 664
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:589 → 621
      ANK; ANK repeat [structural motif]

    11. XM_047446200.1 → XP_047302156.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X6

    12. XM_047446223.1 → XP_047302179.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X17

    13. XM_011510408.4 → XP_011508710.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X14

      Conserved Domains (7) summary
      cd00204
      Location:593 → 687
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:311 → 417
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:320 → 407
      PH; PH domain
      pfam01412
      Location:435 → 552
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:621 → 675
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:600 → 632
      ANK; ANK repeat [structural motif]
      cl12013
      Location:34 → 259
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    14. XM_047446219.1 → XP_047302175.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X16

    15. XM_047446205.1 → XP_047302161.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X13

    16. XM_047446228.1 → XP_047302184.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X18

    17. XM_006711901.4 → XP_006711964.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X10

      Conserved Domains (8) summary
      cd11966
      Location:912 → 967
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:543 → 637
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:261 → 367
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:270 → 357
      PH; PH domain
      pfam01412
      Location:385 → 502
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:571 → 625
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:550 → 582
      ANK; ANK repeat [structural motif]
      cl12013
      Location:3 → 209
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    18. XM_047446202.1 → XP_047302158.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X11

    19. XM_011510409.1 → XP_011508711.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X19

      Conserved Domains (8) summary
      cd11966
      Location:833 → 888
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd00204
      Location:464 → 558
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13251
      Location:182 → 288
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      pfam00169
      Location:191 → 278
      PH; PH domain
      pfam01412
      Location:306 → 423
      ArfGap; Putative GTPase activating protein for Arf
      pfam13857
      Location:492 → 546
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:471 → 503
      ANK; ANK repeat [structural motif]
      cl12013
      Location:1 → 130
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    20. XM_047446229.1 → XP_047302185.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X20

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      9230598..9430981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344382.1 → XP_054200357.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X7

    2. XM_054344378.1 → XP_054200353.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3

    3. XM_054344387.1 → XP_054200362.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X12

    4. XM_054344381.1 → XP_054200356.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X6

    5. XM_054344391.1 → XP_054200366.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X17

    6. XM_054344390.1 → XP_054200365.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X16

    7. XM_054344384.1 → XP_054200359.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X9

    8. XM_054344388.1 → XP_054200363.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X14

    9. XM_054344379.1 → XP_054200354.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X4

    10. XM_054344376.1 → XP_054200351.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1

    11. XM_054344383.1 → XP_054200358.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X8

    12. XM_054344380.1 → XP_054200355.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X5

    13. XM_054344377.1 → XP_054200352.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2

    14. XM_054344389.1 → XP_054200364.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X15

    15. XM_054344392.1 → XP_054200367.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X18

    16. XM_054344385.1 → XP_054200360.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X10

    17. XM_054344386.1 → XP_054200361.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X11

    18. XM_054344393.1 → XP_054200368.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X19

    19. XM_054344394.1 → XP_054200369.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X20

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43150.3 GenPept UniProtKB/Swiss-Prot:O43150

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