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    RSP_RS00510 ActR/PrrA/RegA family redox response regulator transcription factor [ Cereibacter sphaeroides 2.4.1 ]

    Gene ID: 3718682, updated on 26-Dec-2024

    Summary

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    Gene symbol
    RSP_RS00510
    Gene description
    ActR/PrrA/RegA family redox response regulator transcription factor
    Locus tag
    RSP_RS00510
    Gene type
    protein coding
    Organism
    Cereibacter sphaeroides 2.4.1 (strain: 2.4.1, culture-collection: ATCC:BAA-808, type-material: type strain of Rhodobacter sphaeroides)
    Lineage
    Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria; Rhodobacterales; Paracoccaceae; Cereibacter
    Old locus tag
    RSP_1518
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    Genomic context

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    Location:
    chromosome: 1
    Sequence:
    Chromosome: 1; NC_007493.2 (104571..105125, complement)

    Chromosome 1 - NC_007493.2Genomic Context describing neighboring genes Neighboring gene HD domain-containing protein Neighboring gene H-NS family nucleoid-associated regulatory protein Neighboring gene SCO family protein Neighboring gene sensor histidine kinase RegB Neighboring gene PAS-domain containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007493.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the global transcriptional regulator PrrA in Rhodobacter sphaeroides 2.4.1: combined transcriptome and proteome analysis. Eraso JM, et al. J Bacteriol, 2008 Jul. PMID 18487335, Free PMC Article
    2. In vitro and in vivo analysis of the role of PrrA in Rhodobacter sphaeroides 2.4.1 hemA gene expression. Ranson-Olson B, et al. J Bacteriol, 2006 May. PMID 16621813, Free PMC Article
    3. prrA, a putative response regulator involved in oxygen regulation of photosynthesis gene expression in Rhodobacter sphaeroides. Eraso JM, et al. J Bacteriol, 1994 Jan. PMID 8282708, Free PMC Article
    4. Cloning and nucleotide sequence of regA, a putative response regulator gene of Rhodobacter sphaeroides. Phillips-Jones MK, et al. FEMS Microbiol Lett, 1994 Mar 1. PMID 8181698
    5. Regulation of gene expression by PrrA in Rhodobacter sphaeroides 2.4.1: role of polyamines and DNA topology. Eraso JM, et al. J Bacteriol, 2009 Jul. PMID 19411327, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the role of PrrA in the formation of intracytoplasmic membrane
      Title: Analysis of the role of PrrA, PpsR, and FnrL in intracytoplasmic membrane differentiation of Rhodobacter sphaeroides 2.4.1 using transmission electron microscopy.
    2. Study propose that polyamines and DNA supercoiling act synergistically to regulate expression of the RSP3361 gene, partly by affecting the affinity of PrrA binding to the PrrA site 2 within the RSP3361 gene.
      Title: Regulation of gene expression by PrrA in Rhodobacter sphaeroides 2.4.1: role of polyamines and DNA topology.
    3. Study demonstrate that PrrA can bind in vitro to DNA sequences with different lengths in the spacer regions between the half-sites of the RSP3361 gene.
      Title: Half-Site DNA sequence and spacing length contributions to PrrA binding to PrrA site 2 of RSP3361 in Rhodobacter sphaeroides 2.4.1.
    4. While on the one hand, blue light is sensed by the flavin adenine dinucleotide-binding BLUF domain of AppA, on the other, light is absorbed by bacteriochlorophyll signals through PrrB/PrrA.
      Title: In vivo sensitivity of blue-light-dependent signaling mediated by AppA/PpsR or PrrB/PrrA in Rhodobacter sphaeroides.
    5. RegA binds to the cbbI promoter and forms incrementally larger complexes with DNA.
      Title: Protein-protein interactions between CbbR and RegA (PrrA), transcriptional regulators of the cbb operons of Rhodobacter sphaeroides.
    6. The authors showed that PrrA regulation of hemA expression is directed toward the P1 promoter.
      Title: Regulation of the Rhodobacter sphaeroides 2.4.1 hemA gene by PrrA and FnrL.
    7. Approximately 25% of the genes present in the PrrA2 genome are regulated by PrrA at the transcriptional level, either directly or indirectly, by twofold or more relative to the WT.
      Title: Role of the global transcriptional regulator PrrA in Rhodobacter sphaeroides 2.4.1: combined transcriptome and proteome analysis.
    8. Overexpression and purification of the cognate response regulator RegA.
      Title: Purification and assays of Rhodobacter capsulatus RegB-RegA two-component signal transduction system.
    9. Based on our data, we present a model for the interdependence of AppA/PpsR signaling and the PrrA transcriptional activator in light-dependent gene expression.
      Title: The AppA and PpsR proteins from Rhodobacter sphaeroides can establish a redox-dependent signal chain but fail to transmit blue-light signals in other bacteria.
    10. the role of PrrA in hemA regulation
      Title: In vitro and in vivo analysis of the role of PrrA in Rhodobacter sphaeroides 2.4.1 hemA gene expression.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    ActR/PrrA/RegA family redox response regulator transcription factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007493.2 Reference assembly

      Range
      104571..105125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_002722225.1 MULTISPECIES: ActR/PrrA/RegA family redox response regulator transcription factor [Cereibacter]

      See identical proteins and their annotated locations for WP_002722225.1

      UniProtKB/Swiss-Prot
      Q3J6C3, Q53227, Q53228
      UniProtKB/TrEMBL
      A0AAX1UJA8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53228.2