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    PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [ Homo sapiens (human) ]

    Gene ID: 8394, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PIP5K1Aprovided by HGNC
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase type 1 alphaprovided by HGNC
    Primary source
    HGNC:HGNC:8994
    See related
    Ensembl:ENSG00000143398 MIM:603275; AllianceGenome:HGNC:8994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Located in several cellular components, including lamellipodium; nucleus; and ruffle membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 22.2), placenta (RPKM 13.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PIP5K1A in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151195419..151249531)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150319124..150373243)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151171028..151222007)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNFAIP8L2-SCNM1 readthrough Neighboring gene sodium channel modifier 1 Neighboring gene tropomodulin 4 Neighboring gene vacuolar protein sorting 72 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1711 Neighboring gene uncharacterized LOC124904419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1713 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:151183035-151183192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151183741-151184733 Neighboring gene MPRA-validated peak410 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1316 Neighboring gene Sharpr-MPRA regulatory region 10214 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151253738-151254622 Neighboring gene ZNF687 antisense RNA 1 Neighboring gene zinc finger protein 687

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization. Xie Y, et al. Cytogenet Cell Genet, 2000. PMID 10828584
    2. Study of arachidonoyl specificity in two enzymes of the PI cycle. Shulga YV, et al. J Mol Biol, 2011 Jun 3. PMID 21477596, Free PMC Article
    3. The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor. Sarwar M, et al. Oncogene, 2019 Jan. PMID 30104711, Free PMC Article
    4. Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum. Im YJ, et al. Plant Cell, 2007 May. PMID 17496116, Free PMC Article
    5. Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells. Yamaguchi H, et al. Cancer Sci, 2010 Jul. PMID 20426790, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.
      Title: Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.
    2. Human IL-17A protein production is controlled through a PIP5K1alpha-dependent translational checkpoint.
      Title: Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint.
    3. FcgammaRIIIa receptor interacts with androgen receptor and PIP5K1alpha to promote growth and metastasis of prostate cancer.
      Title: FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer.
    4. Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis.
      Title: Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis.
    5. CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.
      Title: CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.
    6. Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.
      Title: Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.
    7. Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein.
      Title: Phosphatidylinositol-4-phosphate 5-kinase type 1α attenuates Aβ production by promoting non-amyloidogenic processing of amyloid precursor protein.
    8. Type I Phosphatidylinositol-4-Phosphate 5-Kinases alpha and gamma Play a Key Role in Targeting HIV-1 Pr55(Gag) to the Plasma Membrane.
      Title: Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55(Gag) to the Plasma Membrane.
    9. The results suggest that PIP5KA is a novel degradative substrate of NEDD4 and that the PIP5KA-dependent phosphatidylinositol 4,5-diphosphate pool contributing to breast cancer cell proliferation through PI3K/Akt activation is negatively controlled by NEDD4.
      Title: NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase α and its implication in breast cancer cell proliferation.
    10. PIP5K1alpha was associated with poor patient outcome in triple-negative BC. It increased expression of pSer-473 AKT and invasiveness of triple-negative MDA-MB-231 cells. Inhibition reduced expression of pSer-473 AKT and its downstream effectors in xenograft tumors. In ER(+) cancer cells, PIP5K1alpha acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of targe...
      Title: The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env-gp120 protein induces PIP(2) production in permissive lymphocytes through the activation of phosphatidylinositol-4-phosphate 5-kinase (PI4P5-K) Ialpha. Cells overexpressing mutant D227A (D/A)-PI4P5-K Ialpha severely reduce HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-5-kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in activation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerophospholipid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in keratinocyte differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phagocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
    Names
    68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
    PIP5K1-alpha
    PIP5KIalpha
    phosphatidylinositol 4-phosphate 5-kinase type I alpha
    ptdIns(4)P-5-kinase 1 alpha
    NP_001129108.1
    NP_001129109.1
    NP_001129110.1
    NP_001317618.1
    NP_003548.1
    XP_005245582.1
    XP_005245584.1
    XP_005245585.1
    XP_005245587.1
    XP_005245589.1
    XP_006711626.1
    XP_006711627.1
    XP_006711630.1
    XP_006711631.2
    XP_011508345.1
    XP_011508347.1
    XP_011508348.1
    XP_011508351.1
    XP_016857928.1
    XP_016857929.1
    XP_024305897.1
    XP_024305898.1
    XP_024305899.1
    XP_047287591.1
    XP_047287594.1
    XP_047287607.1
    XP_047287613.1
    XP_047287614.1
    XP_047287626.1
    XP_047287629.1
    XP_047287631.1
    XP_047287633.1
    XP_047287635.1
    XP_047287637.1
    XP_047287638.1
    XP_047287643.1
    XP_047287650.1
    XP_047287654.1
    XP_047287657.1
    XP_047287658.1
    XP_047287659.1
    XP_047287660.1
    XP_047287662.1
    XP_047287665.1
    XP_047287666.1
    XP_047287668.1
    XP_047287676.1
    XP_047287682.1
    XP_047287685.1
    XP_047287686.1
    XP_047287688.1
    XP_054194987.1
    XP_054194988.1
    XP_054194989.1
    XP_054194990.1
    XP_054194991.1
    XP_054194992.1
    XP_054194993.1
    XP_054194994.1
    XP_054194995.1
    XP_054194996.1
    XP_054194997.1
    XP_054194998.1
    XP_054194999.1
    XP_054195000.1
    XP_054195001.1
    XP_054195002.1
    XP_054195003.1
    XP_054195004.1
    XP_054195005.1
    XP_054195006.1
    XP_054195007.1
    XP_054195008.1
    XP_054195009.1
    XP_054195010.1
    XP_054195011.1
    XP_054195012.1
    XP_054195013.1
    XP_054195014.1
    XP_054195015.1
    XP_054195016.1
    XP_054195017.1
    XP_054195018.1
    XP_054195019.1
    XP_054195020.1
    XP_054195021.1
    XP_054195022.1
    XP_054195023.1
    XP_054195024.1
    XP_054195025.1
    XP_054195026.1
    XP_054195027.1
    XP_054195028.1
    XP_054195029.1
    XP_054195030.1
    XP_054195031.1
    XP_054195032.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135636.2 → NP_001129108.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame coding exons, as compared to variant 1. The resulting isoform (3) is shorter but has identical N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AL592424
      Consensus CDS
      CCDS44220.1
      UniProtKB/Swiss-Prot
      Q99755
      Related
      ENSP00000415648.2, ENST00000441902.6
      Conserved Domains (1) summary
      smart00330
      Location:97 → 409
      PIPKc; Phosphatidylinositol phosphate kinases

    2. NM_001135637.2 → NP_001129109.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 4

      See identical proteins and their annotated locations for NP_001129109.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks 3 nt at an alternate splice site and two in-frame exons in the CDS, as compared to variant 1. The resulting isoform (4) is shorter but has identical N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AL592424
      Consensus CDS
      CCDS44221.1
      UniProtKB/TrEMBL
      B2R729
      Related
      ENSP00000357885.4, ENST00000368890.8
      Conserved Domains (1) summary
      smart00330
      Location:96 → 436
      PIPKc; Phosphatidylinositol phosphate kinases

    3. NM_001135638.2 → NP_001129110.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1

      See identical proteins and their annotated locations for NP_001129110.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL592424
      Consensus CDS
      CCDS44219.1
      UniProtKB/Swiss-Prot
      A8K4Q0, B4DIN0, Q99754, Q99755, Q99756
      Related
      ENSP00000357883.4, ENST00000368888.9
      Conserved Domains (1) summary
      smart00330
      Location:109 → 449
      PIPKc; Phosphatidylinositol phosphate kinases

    4. NM_001330689.2 → NP_001317618.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL592424
      Consensus CDS
      CCDS81374.1
      UniProtKB/TrEMBL
      A6PW57
      Related
      ENSP00000386432.1, ENST00000409426.5

    5. NM_003557.3 → NP_003548.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2

      See identical proteins and their annotated locations for NP_003548.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks 3 nt at an alternate splice site and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) is shorter but has identical N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AL592424
      Consensus CDS
      CCDS990.1
      UniProtKB/Swiss-Prot
      Q99755
      Related
      ENSP00000271663.7, ENST00000349792.9
      Conserved Domains (1) summary
      smart00330
      Location:96 → 436
      PIPKc; Phosphatidylinositol phosphate kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      151195419..151249531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431638.1 → XP_047287594.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

    2. XM_024450129.2 → XP_024305897.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X5

      Conserved Domains (1) summary
      smart00330
      Location:113 → 453
      PIPKc; Phosphatidylinositol phosphate kinases

    3. XM_006711568.5 → XP_006711631.2  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

      Conserved Domains (1) summary
      smart00330
      Location:114 → 454
      PIPKc; Phosphatidylinositol phosphate kinases

    4. XM_011510043.4 → XP_011508345.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

      Conserved Domains (1) summary
      smart00330
      Location:102 → 442
      PIPKc; Phosphatidylinositol phosphate kinases

    5. XM_024450130.2 → XP_024305898.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

      Conserved Domains (1) summary
      smart00330
      Location:101 → 441
      PIPKc; Phosphatidylinositol phosphate kinases

    6. XM_047431658.1 → XP_047287614.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

    7. XM_047431657.1 → XP_047287613.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

    8. XM_047431670.1 → XP_047287626.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

    9. XM_047431681.1 → XP_047287637.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X20

    10. XM_005245530.6 → XP_005245587.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X12

      Conserved Domains (1) summary
      smart00330
      Location:101 → 441
      PIPKc; Phosphatidylinositol phosphate kinases

    11. XM_047431709.1 → XP_047287665.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X29

    12. XM_005245532.5 → XP_005245589.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X15

      Conserved Domains (1) summary
      smart00330
      Location:89 → 429
      PIPKc; Phosphatidylinositol phosphate kinases

    13. XM_047431712.1 → XP_047287668.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X33

    14. XM_047431701.1 → XP_047287657.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X24

    15. XM_011510045.4 → XP_011508347.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X13

      Conserved Domains (1) summary
      smart00330
      Location:100 → 440
      PIPKc; Phosphatidylinositol phosphate kinases

    16. XM_047431710.1 → XP_047287666.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X30

    17. XM_011510046.4 → XP_011508348.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X16

      Conserved Domains (1) summary
      smart00330
      Location:88 → 428
      PIPKc; Phosphatidylinositol phosphate kinases

    18. XM_047431720.1 → XP_047287676.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X34

    19. XM_047431702.1 → XP_047287658.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X25

    20. XM_047431732.1 → XP_047287688.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X38

    21. XM_006711567.5 → XP_006711630.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

      See identical proteins and their annotated locations for XP_006711630.1

      Conserved Domains (1) summary
      smart00330
      Location:73 → 413
      PIPKc; Phosphatidylinositol phosphate kinases

    22. XM_047431698.1 → XP_047287654.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

    23. XM_011510049.4 → XP_011508351.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

      See identical proteins and their annotated locations for XP_011508351.1

      Conserved Domains (1) summary
      smart00330
      Location:73 → 413
      PIPKc; Phosphatidylinositol phosphate kinases

    24. XM_047431694.1 → XP_047287650.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

    25. XM_006711563.5 → XP_006711626.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1

      Conserved Domains (1) summary
      smart00330
      Location:121 → 461
      PIPKc; Phosphatidylinositol phosphate kinases

    26. XM_047431673.1 → XP_047287629.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X14

    27. XM_006711564.5 → XP_006711627.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X6

      Conserved Domains (1) summary
      smart00330
      Location:109 → 449
      PIPKc; Phosphatidylinositol phosphate kinases

    28. XM_047431704.1 → XP_047287660.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X27

    29. XM_047431677.1 → XP_047287633.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X18

    30. XM_005245525.6 → XP_005245582.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2

      Conserved Domains (1) summary
      smart00330
      Location:119 → 459
      PIPKc; Phosphatidylinositol phosphate kinases

    31. XM_005245528.6 → XP_005245585.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X8

      Conserved Domains (1) summary
      smart00330
      Location:107 → 447
      PIPKc; Phosphatidylinositol phosphate kinases

    32. XM_047431635.1 → XP_047287591.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3

    33. XM_047431651.1 → XP_047287607.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X9

    34. XM_047431703.1 → XP_047287659.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X26

    35. XM_047431675.1 → XP_047287631.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X17

    36. XM_017002439.2 → XP_016857928.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X31

    37. XM_047431729.1 → XP_047287685.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X36

    38. XM_005245527.5 → XP_005245584.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X7

      Conserved Domains (1) summary
      smart00330
      Location:108 → 448
      PIPKc; Phosphatidylinositol phosphate kinases

    39. XM_047431706.1 → XP_047287662.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X28

    40. XM_047431679.1 → XP_047287635.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X19

    41. XM_047431726.1 → XP_047287682.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X35

    42. XM_017002440.2 → XP_016857929.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X32

    43. XM_047431687.1 → XP_047287643.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X22

    44. XM_047431730.1 → XP_047287686.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X37

    45. XM_047431682.1 → XP_047287638.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

    46. XM_024450131.2 → XP_024305899.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

      UniProtKB/TrEMBL
      B2R729
      Conserved Domains (1) summary
      smart00330
      Location:61 → 401
      PIPKc; Phosphatidylinositol phosphate kinases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      150319124..150373243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339025.1 → XP_054195000.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

    2. XM_054339022.1 → XP_054194997.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

    3. XM_054339016.1 → XP_054194991.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X5

    4. XM_054339023.1 → XP_054194998.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

    5. XM_054339021.1 → XP_054194996.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X10

    6. XM_054339027.1 → XP_054195002.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

    7. XM_054339026.1 → XP_054195001.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X11

    8. XM_054339035.1 → XP_054195010.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X20

    9. XM_054339015.1 → XP_054194990.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

    10. XM_054339024.1 → XP_054194999.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X12

    11. XM_054339048.1 → XP_054195023.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X29

    12. XM_054339030.1 → XP_054195005.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X15

    13. XM_054339052.1 → XP_054195027.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X33

    14. XM_054339043.1 → XP_054195018.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X24

    15. XM_054339028.1 → XP_054195003.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X13

    16. XM_054339049.1 → XP_054195024.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X30

    17. XM_054339031.1 → XP_054195006.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X16

    18. XM_054339053.1 → XP_054195028.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X34

    19. XM_054339044.1 → XP_054195019.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X25

    20. XM_054339057.1 → XP_054195032.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X38

    21. XM_054339038.1 → XP_054195013.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

    22. XM_054339042.1 → XP_054195017.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

    23. XM_054339037.1 → XP_054195012.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

    24. XM_054339041.1 → XP_054195016.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

    25. XM_054339012.1 → XP_054194987.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1

    26. XM_054339029.1 → XP_054195004.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X14

    27. XM_054339017.1 → XP_054194992.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X6

    28. XM_054339046.1 → XP_054195021.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X27

    29. XM_054339033.1 → XP_054195008.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X18

    30. XM_054339013.1 → XP_054194988.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2

    31. XM_054339019.1 → XP_054194994.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X8

    32. XM_054339014.1 → XP_054194989.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3

    33. XM_054339020.1 → XP_054194995.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X9

    34. XM_054339045.1 → XP_054195020.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X26

    35. XM_054339032.1 → XP_054195007.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X17

    36. XM_054339050.1 → XP_054195025.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X31

    37. XM_054339055.1 → XP_054195030.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X36

    38. XM_054339018.1 → XP_054194993.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X7

    39. XM_054339047.1 → XP_054195022.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X28

    40. XM_054339034.1 → XP_054195009.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X19

    41. XM_054339054.1 → XP_054195029.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X35

    42. XM_054339051.1 → XP_054195026.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X32

    43. XM_054339039.1 → XP_054195014.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X22

    44. XM_054339056.1 → XP_054195031.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X37

    45. XM_054339036.1 → XP_054195011.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X21

    46. XM_054339040.1 → XP_054195015.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X23

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99755.1 GenPept UniProtKB/Swiss-Prot:Q99755

    Gene LinkOut

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